Imran Ahmed¹, Sultan Aljahdali², Muhammad Shakeel Khan¹, Sanaa Kaddoura^3,*

Intelligent Automation & Soft Computing, Vol.32, No.2, pp. 705-722, 2022, DOI:10.32604/iasc.2022.022037 - 17 November 2021

Abstract Parkinson’s disease (PD) is a nervous system disorder first described as a neurological condition in 1817. It is one of the more prevalent diseases in the elderly, and Alzheimer’s is the second most common neurodegenerative illness. It impacts the patient’s movement. Symptoms start gradually with tremors, stiffness in movement, and speech and voice disorders. Researches proved that 89% of patients with Parkinson’s has speech disorder including uncertain articulation, hoarse and breathy voice and monotone pitch. The cause behind this voice change is the reduction of dopamine due to damage of neurons in the substantia nigra… More >

Ahmet Arman¹, Nihal Isık², Ajda Coker³, Fatma Candan², Kezban Serap Becit⁴, Edward O. List⁵

European Cytokine Network, Vol.21, No.2, pp. 116-121, 2010, DOI:10.1684/ecn.2010.0186

Abstract The pathogenesis of Parkinson Disease (PD) remains poorly understood; however, inflammation is thought to play an important role in disease progression. Recent reports suggest that IL-1, a major proinflam-matory cytokine, might play a role in PD progression. The purpose of this study was to determine the relation-ship between IL-1 gene family polymorphisms [IL-1α (-889), IL-1Ra (VNTR) and IL-1β (-511, +3953)] and PD in the Turkish population. In this study, we examined the genotypes of IL-1 gene family polymorphisms in 365 individuals, of which 199 were healthy control subjects and 166 were PD patients. No significant… More >

Mohamed A. Elshaikh¹, Willie Underwood², Daniel E. Soto¹

Canadian Journal of Urology, Vol.16, No.1, pp. 4495-4497, 2009

Abstract We report a case history of a patient with Parkinson’s disease (PD) treated with androgen deprivation therapy (ADT) and external beam radiation for prostate cancer, who developed severe deterioration of his PD during ADT. More >