JOÃO OLIVEIRA PEREIRA^1,2,*, JOÃO GAMA³, DIANA FERREIRA^2,4, ARSÉNIO SANTOS^2,4

Oncology Research, Vol.29, No.2, pp. 81-85, 2021, DOI:10.32604/or.2022.023450

Abstract Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis. Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 10⁹ /L) and extensive osteolytic lesions of the skull on cranioencephalic computer tomography (CT). The patient was stabilized and admitted. Thoracoabdominopelvic CT showed lung parenchyma consolidation with necrotic areas, supra… More >

Hugues Lucron^1,*, Alban-Elouen Baruteau^2,3, Caroline Ovaert⁴, Ali Houeijeh⁵, Mélanie Brard¹, Patrice Guerin², François Bourlon⁶, Claire Dauphin⁷, Saskia Tuttle¹, Maha Tagorti³, Rishika Banydeen⁸, François Godart⁵

Congenital Heart Disease, Vol.17, No.4, pp. 421-436, 2022, DOI:10.32604/chd.2022.020835

Abstract Objectives: We aim to describe the efficacy, safety, and characteristics of the Amplatzer Vascular Plug (AVP) II and IV “off-label” use for multiple cardiovascular occlusions in children under 10 years. Methods: Observational retrospective multicenter (2007–2020, 6 centers) review of paediatric procedures using AVP II or IV. Results: A total of 125 children (49.6% aged ≤ 1 year, 147 lesions) underwent 136 successive procedures (success rate: 98.5%) using 169 devices (109 AVP IV, 60 AVP II). The mean device diameter was 7.7 ± 3.2 mm (4–20 mm). The median AVP size to vessel diameter ratio was 1.3 (0–2). The median age and weight… More > Graphic Abstract

Omnia Shafei^1,2,*, Alyaa A. Kotby^1,2, Mona M. El Ganzoury^1,2, Nevin M. Habeeb^1,2, Eman Elsayed^1,2

Congenital Heart Disease, Vol.17, No.2, pp. 173-185, 2022, DOI:10.32604/CHD.2021.016987

Abstract Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling. Methods: This case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum Gal-3 was measured before, and 1 month after the procedure. Results: Serum Gal-3 concentration, right atrial (RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial performance (RIMP) were significantly… More >

Catherine E. Tomasulo^1,*, Lindsay S. Rogers¹, Lauren Andrade^1,2, Michael L. O’Byrne^1,3,4

Congenital Heart Disease, Vol.17, No.2, pp. 193-199, 2022, DOI:10.32604/chd.2022.017721

Abstract The majority of patients with congenitally corrected transposition of the great arteries, also known as transposition of the great arteries {S,L,L} have ventricular septal defects (VSD), most commonly perimembranous VSD (pmVSD). Transcatheter device closure of pmVSD in these patients has not been widely described. We present a case of device closure of pmVSD in L-TGA with an Amplatzer Duct Occluder II (ADOII) device using a deployment starting in the subpulmonary left ventricle. The case demonstrates some of the technical advantages of the ADOII device for VSD closure, specifically its low profile, symmetric shape, and soft material. These characteristics are advantageous… More >

Marie Laure Yammine^#,*, Camilla Calvieri^#, Marcello Chinali, Salvatore Giannico, Giulia Cafiero, Ugo Giordano

Congenital Heart Disease, Vol.16, No.5, pp. 457-467, 2021, DOI:10.32604/CHD.2021.015896

Abstract Background: In recent decades, aortic stenting has become a promising alternative to surgery for both native aortic coarctation and re-stenosis in children and adults. However, comparative long-term outcomes have poorly been investigated. Methods: We included 212 patients with previous aortic repair (19 ± 8.7 years) divided into 3 groups: 139 with single-time surgical repair (CoA-S group); 18 with single-time percutaneous stenting (CoA-PS group); and 55 hybrid patients with multiple aortic procedures because of re-coarctation occurrence (CoA-H group). All patients underwent 24-hour ambulatory blood pressure monitoring and trans-thoracic echocardiography. Results: After a median follow-up of 17 years after aortic repair, antihypertensive… More >

Matthew I. Jones¹, Matthew Murphy², Eric Rosenthal¹, Kevin P. Walsh^2,3, Damien Kenny^2,3, Shakeel A. Qureshi¹, Gianfranco Butera^1,4,*

Congenital Heart Disease, Vol.16, No.3, pp. 197-203, 2021, DOI:10.32604/CHD.2021.015222

Abstract Objectives: We report our experience of using the 65 cm large diameter GORE^® DrySeal Flex Introducer sheath to facilitate transcatheter implantation of the Venus P-valve in the pulmonary position. Background: Transcatheter implantation of pulmonary valves can be difficult due to rigidity of the valve delivery system or the anatomy of the RVOT and pulmonary artery bifurcation and the risk of iatrogenic damage to the tricuspid valve support apparatus. Using long sheaths to pass and protect the tricuspid valve may facilitate the procedure. Methods: Multi-centre registry of patients who underwent transcatheter pulmonary valve implantation of the Venus P-valve using the GORE^®… More >

Geena Kim¹, Hong Ryang Kil^2,*

Congenital Heart Disease, Vol.16, No.3, pp. 211-220, 2021, DOI:10.32604/CHD.2021.013724

Abstract Background: The influence of the timing of transcatheter atrial septal defect (ASD) closure on ventricular remodeling at 6 months after ASD closure is unclear. This study investigated changes in cardiac remodeling after transcatheter closure of large ASDs according to patient age at the time of the procedure. Methods: In this study, 41 children and 43 adults underwent percutaneous closure of a large ASD. Cardiac remodeling was assessed by two-dimensional echocardiography and electrocardiography before and at 6 months after ASD closure. Results: The age of the children and adults were 2.8 ± 3.1 and 50.0 ± 15.6 years, respectively. The Qp/Qs… More >

Biagio Castaldi^1,*, Giulio Cabrelle¹, Massimo Padalino², Vladimiro Vida², Ornella Milanesi¹, Giovanni Di Salvo¹

Congenital Heart Disease, Vol.15, No.5, pp. 347-360, 2020, DOI:10.32604/CHD.2020.012750

Abstract Background: Trans-catheter closure has become the treatment of choice for patent foramen ovale (PFO) and ostium secundum atrial septal defects (ASD). A wide variety of devices are commercially available, however, concerns have been raised about the risk of cardiac erosion associated with stiff/rigid devices. The GORE® CARDIOFORM Septal Occluder (GSO) is a double-disc, soft and conformable device with no reported incidence of cardiac erosions. However, wire frame fracture (WFF) have been reported. Aim: To assess the incidence and clinical significance of WFF after GSO implantation in paediatric patients. Methods: Seventy-seven consecutive patients were enrolled. Periprocedural and follow-up assessments included clinical,… More >

Alejandro R. Peirone^1,*, Alejandro E. Contreras², Carolina Carrizo², Mailén Konicoff², Raúl O. Cayre³

Congenital Heart Disease, Vol.15, No.4, pp. 267-274, 2020, DOI:10.32604/CHD.2020.013199

Abstract A 43-year-old woman with a past medical history of aortic coarctation surgically repaired at the age of 3 years using an end-to-end anastomosis, presented with 2 years complain of increasing dyspnea and fatigue with exercise associated to frequent palpitations. During extensive work-up, she was found to have a partial anomalous pulmonary venous connection (PAPVC) with “dual drainage” represented by a communication between the right pulmonary veins draining into the left atrium and the innominate vein via an anomalous vein due to a persistence of early connections between the sinus of the right pulmonary veins and the cardinal veins system in… More >

Maria Drakopoulou¹, George Oikonomou¹, Stergios Soulaidopoulos¹, Basil Thanopoulos², Konstantina Aggeli¹, Dimitrios Tousoulis¹, Konstantinos Toutouzas^1,*

Congenital Heart Disease, Vol.15, No.3, pp. 147-151, 2020, DOI:10.32604/CHD.2020.011338

Abstract The percutaneous closure of ostium secundum atrial septal defects (ASD) is a well-established procedure. Currently available devices and delivery systems are designed to be used via the femoral venous route. However, an alternative approach needs to be considered in cases of congenital or acquired caval obstruction. We describe a successful transjugular closure of a moderate sized secundum ASD with the Cocoon Septal Occluder in a 37-year-old symptomatic woman with inferior vena cava (IVC) thrombosis, using a novel deployment technique to overcome difficulties, namely maintaining stable sheath position in the left atrium. Percutaneous closure of secundum ASDs via the transjugular approach… More >