JIYU WANG^1,#, LIUYING YI^2,#, KEKE HUANG¹, YANGYANG WANG¹, HUIPING WANG¹, ZHIMIN ZHAI^1,*

BIOCELL, Vol.48, No.3, pp. 453-462, 2024, DOI:10.32604/biocell.2024.047871

Abstract Background: The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma (r/r B-NHL) is resistance to current therapies, and therapy-induced senescence (TIS) stands out as a crucial mechanism contributing to tumor drug resistance. Here, we analyzed SENEX/Rho GTPase Activating Protein 18 (ARHGAP18) expression and prognostic significance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients, investigating its target in B-NHL cell senescence and the effect of combining specific inhibitors on apoptosis resistance in B-NHL-TIS cells. Methods: Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector (Sh-SENEX) and the empty vector negative (NC) to… More >

Miao He^1,2, Yihang Zhang^1,*, Mingbiao Xu^1,2,*, Jun Li³

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.5, pp. 1031-1046, 2020, DOI:10.32604/fdmp.2020.011145

Abstract This study presents a new multiphase flow model with transient heat transfer and pressure coupling to simulate HTHP (high temperature and high pressure) sour gas “kicks” phenomena. The model is intended to support the estimation of wellbore temperature and pressure when sour gas kicks occur during drilling operation. The model considers sour gas solubility, phase transition and effects of temperature and pressure on the physical parameters of drilling fluid. Experimental data for a large-diameter pipe flow are used to validate the model. The results indicate that with fluid circulation, the annulus temperature with H₂S kicks is the highest, followed by… More >

Tao Li¹, Qingsheng Yang^{1, *}, Lianhua Ma², Xiaojun Zhang^{2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.3, pp. 995-1014, 2020, DOI:10.32604/cmes.2020.09152

Abstract Phase transition of hydrogel, which is polymerized by polymer network, can be regarded as the transition of polymer network stability. The stability of the polymer network might be changed when the external environment changed. This change will lead to the transformation of sensitive hydrogels stability, thus phase transition of hydrogel take place. Here, we present a new free density energy function, which considers the non-gaussianity of the polymer network, chains entanglement and functionality of junctions through adding Gent hyplastic model and Edwards-Vilgis slip-link model to Flory-Huggins theory. A program to calculate the phase transition temperature was written based on new… More >

Sheng Sun, Joseph T. Y. Wong, Tong-Yi Zhang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.2, pp. 45-46, 2011, DOI:10.3970/icces.2011.017.045

Abstract Lipids in water form different structures (or phases) via self-assembly depending on hydration level of lipid. As the hydration level of lipid increases, the self-assembled structures are micelles, cylinder phase, lamellar phase, and inverted cylinder phase. Lamellar phase or bilayer is the most common structure in cells. Experiments reveal that external electric fields can induce cell membrane poration and fusion, and the technique is widely used to transfer external molecules, such as DNA and drugs, into cells.

By using molecular dynamics simulations, we studied the behaviors of pure phospholipid membrane bilayer in an external electric field, which was applied… More >

Victor A. Eremeyev

The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.3, pp. 81-82, 2011, DOI:10.3970/icces.2011.019.081

Abstract The aim of this work is to discuss the nonlinear theory of shells made of material undergoing phase transitions (PT). The interest to mechanics and thermodynamics of thin-walled structures with PT is motivated by the recent investigations of thin martensitic films and biological membranes. Here we present statements of the boundary-value problems of shells and plates with PT within the dynamically and kinematically exact theory of shells. In this shell theory the translation and rotation fields are the kinematically independent variables. The theoretical model is illustrated by the examples of thin circular cylindrical shell and circular plate made of two-phase… More >

Michael Yu Wang^1,2, Shiwei Zhou²

CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.6, pp. 547-566, 2004, DOI:10.3970/cmes.2004.006.547

Abstract In this paper we present a variational method to address the topology optimization problem -- the phase transition method. A phase-field model is employed based on the phase-transition theory in the fields of mechanics and material sciences. The topology optimization is formulated as a continuous problem with the phase-field as design variables within a fixed reference domain. All regions are described in terms of the phase field which makes no distinction between the solid, void and their interface. The Van der Waals-Cahn-Hilliard theory is applied to define the variational topology optimization as a dynamic process of phase transition. The Γ-convergence… More >