Ying Fang^1,2,3,#, Anqi Wu^2,4,#, Yu-Sheng Cong^5,*, Guoqing Li^1,2,*

Oncology Research, Vol.33, No.11, pp. 3231-3245, 2025, DOI:10.32604/or.2025.066402 - 22 October 2025

Abstract Gastric Cancer (GC) is a highly prevalent and poorly prognostic gastrointestinal malignancy with low overall treatment efficacy worldwide. Early diagnostic markers and potential therapeutic targets for GC treatment are urgently needed. UFMylation, a novel ubiquitin-like modification is indispensable for numerous fundamental cellular processes. Deficiency in this modification is reported to be associated with several human diseases including cancer. Accumulating evidence suggests that the expression of the key UFMylation components is closely associated with GC cell proliferation, invasion, metastasis, and chemotherapy resistance. Recent clinical studies have further highlighted the prognostic value and therapeutic potential of UFMylation More >

Yuriy E. Kolupaev^1,2,*, Tetiana O. Yastreb^1,*, Alexander P. Dmitriev³

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3151-3195, 2024, DOI:10.32604/phyton.2024.057922 - 31 December 2024

Abstract Stomatal closure, which serves to limit water loss, represents one of the most rapid and critical reactions of plants, occurring not only in response to drought but also to a range of other stressors, including salinity, extreme temperatures, heavy metals, gaseous toxicants, and pathogen infection. ABA is considered to be the main regulator of stomatal movements in plants under abiotic stress. In the last two decades, however, the list of plant hormones and other physiologically active substances that affect stomatal status has expanded considerably. It is believed that stomata are regulated by a complex multicomponent… More >

Shaheena Khanum¹, Muhammad Adeel Ashraf², Asim Karim¹, Bilal Shoaib³, Muhammad Adnan Khan⁴, Rizwan Ali Naqvi⁵, Kamran Siddique⁶, Mohammed Alswaitti^6,*

CMC-Computers, Materials & Continua, Vol.66, No.2, pp. 2165-2181, 2021, DOI:10.32604/cmc.2020.013646 - 26 November 2020

Abstract Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide. It is a clinically important attribute to numerous age-related, metabolic, and chronic diseases such as diabetes, Alzheimer’s, renal failure, etc. Identification of a non-enzymatic reaction are quite challenging in research. Manual identification in labs is a very costly and time-consuming process. In this research, we developed an accurate, valid, and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites. Comprehensive techniques using position relative features are used for feature extraction. An algorithm named as a… More >