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Search Results (7)
  • Open Access

    REVIEW

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

    ELYN AMIELA SALLEH1, YEONG YEH LEE2, ANDEE DZULKARNAEN ZAKARIA3, NUR ASYILLA CHE JALIL4, MARAHAINI MUSA1,*

    BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

    Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More > Graphic Abstract

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

  • Open Access

    REVIEW

    DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review

    QIAO ZHOU1,2,3, JIAN LIU2,4, LING XIN4, YANYAN FANG2,4, LEI WAN2,4, DAN HUANG2,4, JINCHEN GUO1, JIANTING WEN2,4

    BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698

    Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease… More >

  • Open Access

    ARTICLE

    Exosomes: Key tools for cancer liquid biopsy

    ISABELLA PANFOLI1,*, MAURIZIO BRUSCHI2, GIOVANNI CANDIANO2

    BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154

    Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the rest of the body, promoting… More >

  • Open Access

    VIEWPOINT

    Biomarkers for targeted rehabilitation strategies after breast cancer: Proposal for the next-generation management of survivorship issues

    MARCO INVERNIZZI1,2,*, NICOLA FUSCO3,4,*

    BIOCELL, Vol.46, No.10, pp. 2221-2223, 2022, DOI:10.32604/biocell.2022.021043

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Multi-Disease Prediction Based on Deep Learning: A Survey

    Shuxuan Xie, Zengchen Yu, Zhihan Lv*

    CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.2, pp. 489-522, 2021, DOI:10.32604/cmes.2021.016728

    Abstract In recent years, the development of artificial intelligence (AI) and the gradual beginning of AI’s research in the medical field have allowed people to see the excellent prospects of the integration of AI and healthcare. Among them, the hot deep learning field has shown greater potential in applications such as disease prediction and drug response prediction. From the initial logistic regression model to the machine learning model, and then to the deep learning model today, the accuracy of medical disease prediction has been continuously improved, and the performance in all aspects has also been significantly improved. This article introduces some… More >

  • Open Access

    ARTICLE

    Secure Sharing Scheme of Sensitive Data in the Precision Medicine System

    Deukhun Kim1, Heejin Kim2, Jin Kwak3, *

    CMC-Computers, Materials & Continua, Vol.64, No.3, pp. 1527-1553, 2020, DOI:10.32604/cmc.2020.010535

    Abstract Numerous industries, especially the medical industry, are likely to exhibit significant developments in the future. Ever since the announcement of the precision medicine initiative by the United States in 2015, interest in the field has considerably increased. The techniques of precision medicine are employed to provide optimal treatment and medical services to patients, in addition to the prevention and management of diseases via the collection and analysis of big data related to their individual genetic characteristics, occupation, living environment, and dietary habits. As this involves the accumulation and utilization of sensitive information, such as patient history, DNA, and personal details,… More >

  • Open Access

    ARTICLE

    Epigenetics for the pediatric cardiologist

    Andrew D. Spearman

    Congenital Heart Disease, Vol.12, No.6, pp. 828-833, 2017, DOI:10.1111/chd.12543

    Abstract A genetic basis of congenital heart disease (CHD) has been known for decades. In addition to the sequence of the genome, the contribution of epigenetics to pediatric cardiology is increasingly recognized. Multiple epigenetic mechanisms, including DNA methylation, histone modification, and RNA-based regulation, are known mediators of cardiovascular disease, including both development and progression of CHD and its sequelae. Basic understanding of the concepts of epigenetics will be essential to all pediatric cardiologists in order to understand mechanisms of pathophysiology, pharmacotherapeutic concepts, and to understand the role of epigenetics in precision medicine. More >

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