Kailyn Anderson1, James Cnota2,3, Jeanne James4,5, Erin M. Miller2,3, Ashley Parrott3, Valentina Pilipenko1,2, Kathryn Nicole Weaver1,2, Amy Shikany3
Congenital Heart Disease, Vol.14, No.2, pp. 264-273, 2019, DOI:10.1111/chd.12721
Abstract Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.
Design: A retrospective chart review of 204 patients diagnosed with vPS between
9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of
Noonan syndrome were collected. Chi‐square test, Fisher’s exact test, t test,
Wilcoxon rank‐sum test, and ANOVA were used for comparisons among the groups.
Logistic regression was used to test for the association between… More >
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