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  • Open Access

    ARTICLE

    Agmatine pretreatment protects retinal ganglion cells (RGC-5 cell line) from oxidative stress in vitro

    IIZUKA YOKO1, SAMIN HONG2, CHAN YUN KIM2, SEUNG KAB KIM2, GONG JE SEONG2

    BIOCELL, Vol.32, No.3, pp. 245-250, 2008, DOI:10.32604/biocell.2008.32.245

    Abstract Agmatine, 2-(4-aminobutyl)guanidine, has been reported to have neuroprotective effects against various neuronal damages. In this study it was investigated whether agmatine pretreatment rescues the retinal ganglion cells from oxidative injury in vitro. After differentiation of transformed rat retinal ganglion cells (RGC-5 cell line) with staurosporine, agmatine (0.0 to 100.0 μM) pretreatment was performed for 2 hours. Subsequently, they were exposed to hydrogen peroxide (0.0 to 2.5 mM) as an oxidative stress. Cell viability was monitored for up to 48 hours with the lactate dehydrogenase (LDH) assay and apoptosis was examined by the terminal deoxynucleotide transferase-mediated terminal uridine deoxynucleotidyl transferase nick… More >

  • Open Access

    ARTICLE

    PGPR inoculation improves growth, nutrient uptake and physiological parameters of Capsicum chinense plants

    Castillo-Aguilar C de la C1, JJ Zúñiga-Aguilar2, AA Guzmán-Antonio2, R Garruña3

    Phyton-International Journal of Experimental Botany, Vol.86, pp. 199-204, 2017, DOI:10.32604/phyton.2017.86.199

    Abstract The Habanero pepper (Capsicum chinense) is intensively cultivated in the Yucatan peninsula, México. Because of adverse environmental conditions, it required seeding in germination trays, from which six-week-old seedlings were transplanted to the soil. Adequate nursing and fertilization programmes were made to improve health and vigour before seedlings transplanting. During seed germination, we investigated the effects of inoculation with four plant growth-promoting rhizobacteria (PGPR) on growth, nutrient uptake and gas exchange of 8-week-old Capsicum chinense plants. Inoculation was made with Pseudomonas sp. -P61-, Pseudomonas sp. -A46-, Bacillus pumillus -R44-, and Paenibacillus polymyxa-BSP1.1-. The BSP1.1 strain produced the highest increase in plant… More >

  • Open Access

    ABSTRACT

    LOX Alleviates Rat Intervertebral Disc Degeneration Through ECM Improvement and Anti-Apoptotic Protection in Nucleus Pulposus Cells

    Runze Zhao1, Tingting Xia1, Mengyue Wang1, Fan Feng1, Wanqian Liu1,*, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 77-77, 2019, DOI:10.32604/mcb.2019.07155

    Abstract This study was focus on the exploring the therapeutic function of lysyl oxidase (LOX) in rat nucleus pulposus (NP) cells in intervertebral disc degeneration (IVDD). To do this, a Sprague-Dawley (SD) rat caudal spine degeneration model was established by puncturing the Co5-6 disc. NP cells apoptosis and extracellular matrix (ECM) degeneration in IVDD were evaluated by real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), Hematoxylin-Eosin (H&E) and immunofluorescence. Then, the therapeutic effect of LOX on IVDD was evaluated by histological staining. In vitro, the regulator effect of LOX on degenerate rat NP cell was explored. ECM relate proteins and cytokines were… More >

  • Open Access

    ABSTRACT

    Protecting the Brain from Calcification in Ischemic Stroke

    Shu Q. Liu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Antimalarial drug artesunate aff ords protection against carrageenan induced acute infl ammation in rat

    Vijay L. KUMAR1 *, B. GURUPRASAD1, Priyanka CHAUDHARY2

    BIOCELL, Vol.38, No.1, pp. 1-6, 2014, DOI:10.32604/biocell.2014.38.001

    Abstract Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of artesunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of 0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE2 and myeloperoxidase were estimated in the inflamed… More >

  • Open Access

    ARTICLE

    Spontaneous running wheel improves neuroprotection efficacy of ischemic postconditioning in mice following ischemia/reperfusion injury

    Hong YE1,6,#, WeiWei Wang2,#, Yu Ding3,#, XiaoLei Liu4,#, WenJI Jia1, WeiLi Luo1, HuiJuan Fan1, HongQun Zhou1, Jin Wang1, JianLong Ju1, DongMing Zhou7, TianHao Bao5,1,*, YuHong Zhu1,*

    BIOCELL, Vol.42, No.3, pp. 79-86, 2018, DOI:10.32604/biocell.2018.04615

    Abstract Ischemic postconditioning (IP) has been shown to provide protection for ischemia/reperfusion (IR) injury, but its efficacy is limited. In this study we hypothesized that spontaneous running wheel (RW) could improve neuroprotection efficacy of IP for IR. We established mouse models of IR and showed that compared to Sham group, IR group had obvious brain infract and neurological dysfunction. In IR+IP group, brain infract and neurological dysfunction improved compared to IR group. However, in IR+IP+RW group brain infract and neurological dysfunction improved much better. TUNEL assay showed that IP but not RW significantly reduced the number of apoptotic cells after IR.… More >

  • Open Access

    ARTICLE

    Research on the Association of Mobile Social Network Users Privacy Information Based on Big Data Analysis

    Pingshui Wang1,*, Zecheng Wang1, Qinjuan Ma1

    Journal of Information Hiding and Privacy Protection, Vol.1, No.1, pp. 35-42, 2019, DOI:10.32604/jihpp.2019.05942

    Abstract The issue of privacy protection for mobile social networks is a frontier topic in the field of social network applications. The existing researches on user privacy protection in mobile social network mainly focus on privacy preserving data publishing and access control. There is little research on the association of user privacy information, so it is not easy to design personalized privacy protection strategy, but also increase the complexity of user privacy settings. Therefore, this paper concentrates on the association of user privacy information taking big data analysis tools, so as to provide data support for personalized privacy protection strategy design. More >

  • Open Access

    ARTICLE

    A Survey on Cryptographic Security and Information Hiding Technology for Cloud or Fog-Based IoT System

    Liang Bai1, Yuzhen Liu1, Xiaoliang Wang1,*, Nick Patterson2, F. Jiang2

    Journal of Information Hiding and Privacy Protection, Vol.1, No.1, pp. 1-10, 2019, DOI:10.32604/jihpp.2019.06043

    Abstract Internet of Things (IoT) is an emerging paradigm involving intelligent sensor networks that incorporates embedded technology for collecting data, communicating with external environments. Recently, cloud computing together with fog computing has become an important research area of the Internet of Things because of big data processing capabilities. It is a promising technology that utilizes cloud or fog computing / architecture to improve sensor computing, storage, and communication capabilities. However, recently it has been shown that this computing/architecture may be vulnerable to various attacks because of the openness nature of the wireless network. Therefore, it becomes more and more important to… More >

  • Open Access

    REVIEW

    Systems Neuroprotective Mechanisms in Ischemic Stroke

    Shu Q. Liu*

    Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 75-85, 2019, DOI:10.32604/mcb.2019.06920

    Abstract Ischemic stroke, although causing brain infarction and neurological deficits, can activate innate neuroprotective mechanisms, including regional mechanisms within the ischemic brain and distant mechanisms from non-ischemic organs such as the liver, spleen, and pancreas, supporting neuronal survival, confining brain infarction, and alleviating neurological deficits. Both regional and distant mechanisms are defined as systems neuroprotective mechanisms. The regional neuroprotective mechanisms involve release and activation of neuroprotective factors such as adenosine and bradykinin, inflammatory responses, expression of growth factors such as nerve growth factors and neurotrophins, and activation and differentiation of resident neural stem cells to neurons and glial cells. The distant… More >

  • Open Access

    ARTICLE

    A Novel Reversible Data Hiding Scheme Based on Lesion Extraction and with Contrast Enhancement for Medical Images

    Xingxing Xiao1, Yang1,*, Rui Li2, Weiming Zhang3

    CMC-Computers, Materials & Continua, Vol.60, No.1, pp. 101-115, 2019, DOI:10.32604/cmc.2019.05293

    Abstract The medical industry develops rapidly as science and technology advance. People benefit from medical resource sharing, but suffer from privacy leaks at the same time. In order to protect patients’ privacy and improve quality of medical images, a novel reversible data hiding (RDH) scheme based on lesion extraction and with contrast enhancement is proposed. Furthermore, the proposed scheme can enhance the contrast of medial image's lesion area directly and embed high-capacity privacy data reversibly. Different from previous segmentation methods, this scheme first adopts distance regularized level set evolution (DRLSE) to extract lesion and targets at the lesion area accurately for… More >

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