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  • Open Access

    ARTICLE

    Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways: An in vivo and a network pharmacology assessment

    LINGYAN LV1,2,#, JING ZHAO1,2,#, XUAN WANG1,2, LIUYAN XU1,2, YINGYI FAN2, CHUNHUI WANG3, HONGQIAO FAN4,5,*, XIAOHUA PEI5,*

    BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

    Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

  • Open Access

    ARTICLE

    Study on the Relationship between Mental Health Literacy and Psychological Symptoms of University Students: Mediating Effect of Grit

    Yeo-Won Jeong1, Jung-Ha Kim2,*, Hyun-Kyeong Park3

    International Journal of Mental Health Promotion, Vol.25, No.7, pp. 813-821, 2023, DOI:10.32604/ijmhp.2023.027383

    Abstract Background: The occurrence of mental health symptoms is higher in individuals aged between 18 and 24 years than in other age groups. Mental health literacy is derived from health literacy, and focuses on the knowledge, attitudes, and competencies that individuals need to acquire to manage their own health effectively. Low mental health literacy is associated with poorer mental health. Grit is also a known protective factor against mental disorders. Despite a heightened focus on mental health literacy and grit as important factors for decreasing mental health symptoms, knowledge of the effect of mental health literacy and grit on mental health… More >

  • Open Access

    ARTICLE

    Stressors and Coping Strategies of Medical Staff in the COVID-19 Pandemic in Wuhan

    Long Liu1,2, Yanlin Shi1,*, Xiyan Fei3, Zhenzhen Wang1,4, Zhi Wang1,5, Li Li6, Lin Ding6, Qiaoyuan Yan7,*

    International Journal of Mental Health Promotion, Vol.23, No.3, pp. 319-330, 2021, DOI:10.32604/IJMHP.2021.015699

    Abstract Exploring whether medical staff perceive stress on the assigned medical tasks, what are the specific sources of stress, what are the tangible sources of support they expected to be helpful, and individual coping with stress to provide more accurate, personal support for psychological crisis. This study uses a cross-sectional descriptive survey adopting convenience sampling among the medical staff who worked for over seven days in the infected areas of one Grade 2A and three Grade 3A hospitals during the COVID-19 pandemic. The assessment includes attitude when receiving tasks, major stressors, factors relieving stress, and personal management of stress. A total… More >

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