Damodharan Palaniappan¹, Tan Kuan Tak², K. Vijayan³, Balajee Maram⁴, Pravin R Kshirsagar⁵, Naim Ahmad^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4107-4127, 2025, DOI:10.32604/cmes.2025.073387 - 23 December 2025

Abstract A phase-aware cross-modal framework is presented that synthesizes UWF_FA from non-invasive UWF_RI for diabetic retinopathy (DR) stratification. A curated cohort of 1198 patients (2915 UWF_RI and 17,854 UWF_FA images) with strict registration quality supports training across three angiographic phases (initial, mid, final). The generator is based on a modified pix2pixHD with an added Gradient Variance Loss to better preserve microvasculature, and is evaluated using MAE, PSNR, SSIM, and MS-SSIM on held-out pairs. Quantitatively, the mid phase achieves the lowest MAE (98.76 ± 42.67), while SSIM remains high across phases. Expert review shows substantial agreement (Cohen’s More >

Maheen Anwar¹, Saima Farhan¹, Yasin Ul Haq², Waqar Azeem³, Muhammad Ilyas⁴, Razvan Cristian Voicu^5,*, Muhammad Hassan Tanveer⁵

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3477-3502, 2025, DOI:10.32604/cmc.2025.065141 - 03 July 2025

Abstract Glaucoma, a chronic eye disease affecting millions worldwide, poses a substantial threat to eyesight and can result in permanent vision loss if left untreated. Manual identification of glaucoma is a complicated and time-consuming practice requiring specialized expertise and results may be subjective. To address these challenges, this research proposes a computer-aided diagnosis (CAD) approach using Artificial Intelligence (AI) techniques for binary and multiclass classification of glaucoma stages. An ensemble fusion mechanism that combines the outputs of three pre-trained convolutional neural network (ConvNet) models–ResNet-50, VGG-16, and InceptionV3 is utilized in this paper. This fusion technique enhances… More >

Anand Deva Durai Chelladurai¹, Theena Jemima Jebaseeli², Omar Alqahtani¹, Prasanalakshmi Balaji^1,*, Jeniffer John Simon Christopher³

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1101-1122, 2025, DOI:10.32604/cmc.2025.062278 - 09 June 2025

Abstract Optical Coherence Tomography (OCT) provides cross-sectional and three-dimensional reconstructions of the target tissue, allowing precise imaging and quantitative analysis of individual retinal layers. These images, based on optical inhomogeneities, reveal intricate cellular structures and are vital for tasks like retinal segmentation. The proposed study uses OCT images to identify significant differences in peripapillary retinal nerve fiber layer thickness. Incorporating spectral-domain analysis of OCT images significantly enhances the evaluation of Purtcher Retinopathy. To streamline this process, the study introduces a Context Encoding Deep Neural Network (CEDNN), which eliminates the time-consuming manual segmentation process while improving the… More >

Kachi Anvesh^1,2, Bharati M. Reshmi^2,3, Shanmugasundaram Hariharan⁴, H. Venkateshwara Reddy⁵, Murugaperumal Krishnamoorthy⁶, Vinay Kukreja⁷, Shih-Yu Chen^8,9,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.2, pp. 1485-1517, 2025, DOI:10.32604/cmes.2025.063239 - 30 May 2025

Abstract Automated classification of retinal fundus images is essential for identifying eye diseases, though there is earlier research on applying deep learning models designed especially for detecting tessellation in retinal fundus images. This study classifies 4 classes of retinal fundus images with 3 diseased fundus images and 1 normal fundus image, by creating a refined VGG16 model to categorize fundus pictures into tessellated, normal, myopia, and choroidal neovascularization groups. The approach utilizes a VGG16 architecture that has been altered with unique fully connected layers and regularization using dropouts, along with data augmentation techniques (rotation, flip, and… More >

Nicholas T. Bello¹, Bonnie L. Firestein², Maribel Vazquez^3,*

BIOCELL, Vol.49, No.3, pp. 349-354, 2025, DOI:10.32604/biocell.2025.061810 - 31 March 2025

Abstract Neurodegeneration of retinal tissue leads to progressive vision loss in millions of working-age adults each year. Metabolic alterations caused by modern diets that are high in fats and sugars contribute to the development of diabetic retinopathy. Chronic, diet-induced metabolic changes are linked to high glucose and harmful, pro-inflammatory compounds in the blood, called advanced glycation end products (AGEs), that can alter the integrity of neurovascular barriers. AGEs-induced changes to the permeability of the inner blood-retinal barrier can lead to progressive vision loss with disparate impacts in patients with low estrogen, such as via natural aging More >

Tariq Mahmood^1,2, Tanzila Saba¹, Faten S. Alamri^3,*, Alishba Tahir⁴, Noor Ayesha⁵

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1173-1193, 2025, DOI:10.32604/cmc.2025.061150 - 26 March 2025

Abstract Innovation in learning algorithms has made retinal vessel segmentation and automatic grading techniques crucial for clinical diagnosis and prevention of diabetic retinopathy. The traditional methods struggle with accuracy and reliability due to multi-scale variations in retinal blood vessels and the complex pathological relationship in fundus images associated with diabetic retinopathy. While the single-modal diabetic retinopathy grading network addresses class imbalance challenges and lesion representation in fundus image data, dual-modal diabetic retinopathy grading methods offer superior performance. However, the scarcity of dual-modal data and the lack of effective feature fusion methods limit their potential due to… More >

Chengzhang Zhu^1,2, Ahmed Alasri¹, Tao Xu³, Yalong Xiao^1,2,*, Abdulrahman Noman¹, Raeed Alsabri¹, Xuanchu Duan⁴, Monir Abdullah⁵

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 5153-5167, 2025, DOI:10.32604/cmc.2024.058647 - 06 March 2025

Abstract Globally, diabetic retinopathy (DR) is the primary cause of blindness, affecting millions of people worldwide. This widespread impact underscores the critical need for reliable and precise diagnostic techniques to ensure prompt diagnosis and effective treatment. Deep learning-based automated diagnosis for diabetic retinopathy can facilitate early detection and treatment. However, traditional deep learning models that focus on local views often learn feature representations that are less discriminative at the semantic level. On the other hand, models that focus on global semantic-level information might overlook critical, subtle local pathological features. To address this issue, we propose an… More >

Jahida Subhedar^1,2, Anurag Mahajan^1,*, Shabana Urooj³, Neeraj Kumar Shukla^4,5

CMC-Computers, Materials & Continua, Vol.82, No.2, pp. 2831-2847, 2025, DOI:10.32604/cmc.2025.059350 - 17 February 2025

Abstract Retinal Optical Coherence Tomography (OCT) images, a non-invasive imaging technique, have become a standard retinal disease detection tool. Due to disease, there are morphological and textural changes in the layers of the retina. Classifying OCT images is challenging, as the morphological manifestations of different diseases may be similar. The OCT images capture the reflectivity characteristics of the retinal tissues. Retinal diseases change the reflectivity property of retinal tissues, resulting in texture variations in OCT images. We propose a hybrid approach to OCT image classification in which the Convolution Neural Network (CNN) model is trained using… More >

Mohammed Salih Ahmed¹, Atta Rahman^2,*, Yahya Alhabboub¹, Khalid Alzahrani¹, Hassan Baragbah¹, Basel Altaha¹, Hussein Alkatout¹, Sardar Asad Ali Biabani^3,4, Rashad Ahmed⁵, Aghiad Bakry²

Intelligent Automation & Soft Computing, Vol.40, pp. 149-175, 2025, DOI:10.32604/iasc.2025.059080 - 12 February 2025

Abstract This study rigorously evaluates the potential of transfer learning in diagnosing retinal eye diseases using advanced models such as YOLOv8, Xception, ConvNeXtTiny, and VGG16. All models were trained on the esteemed RFMiD dataset, which includes images classified into six critical categories: Diabetic Retinopathy (DR), Macular Hole (MH), Diabetic Neuropathy (DN), Optic Disc Changes (ODC), Tesselated Fundus (TSLN), and normal cases. The research emphasizes enhancing model performance by prioritizing recall metrics, a crucial strategy aimed at minimizing false negatives in medical diagnostics. To address the challenge of imbalanced data, we implemented effective preprocessing techniques, including cropping,… More >

WENBIN LUO¹, YULING ZOU², HONGXI WU³, ZHONGYI YANG¹, ZHIPENG YOU^2,*

BIOCELL, Vol.48, No.8, pp. 1275-1284, 2024, DOI:10.32604/biocell.2024.051045 - 02 August 2024

Abstract Background: Diabetes retinopathy (DR) is a complication of diabetes that affects patients’ vision. Previous studies have found blueberry anthocyanins extract (BAE) can inhibit the progression of DR, but its mechanism is not completely clear. Methods: To study the role of BAE in diabetes retinopathy, we treated human retinal endothelial cells (HRCECs) with 30 mM high glucose to simulate the microenvironment of diabetes retinopathy and used BAE to intervene the in vitro high glucose-induced retinopathy model. HRCEC cell viability and apoptosis rates were examined by Cell Counting Kit 8 (CCK-8) assay and flow cytometry assay. The binding… More >