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  • Open Access

    ARTICLE

    Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study

    Cheng-Hsun Chuang1,2,3,#, Ping-Kun Tsai3,4,5,6,#, Shih-Wen Kao7,8, Yu-Hsun Wang8,9,*, Chao-Bin Yeh1,2,3,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072875 - 30 December 2025

    Abstract Background: To determine whether initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within 3 months of type 2 diabetes (T2DM) diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index (BMI). Methods: This retrospective cohort study used electronic health records from the TriNetX U.S. research network. Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis. Following 1:1 propensity score matching, both the GLP-1 RA user and non-user… More > Graphic Abstract

    Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study

  • Open Access

    ARTICLE

    Optimal Operation of Virtual Power Plants Based on Revenue Distribution and Risk Contribution

    Heping Qi, Wenyao Sun*, Yi Zhao, Xiaoyi Qian, Xingyu Jiang

    Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069603 - 27 December 2025

    Abstract Virtual power plant (VPP) integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions, promote the consumption of renewable energy, and improve economic efficiency. In this paper, aiming at the uncertainty of distributed wind power and photovoltaic output, considering the coupling relationship between power, carbon trading, and green card market, the optimal operation model and bidding scheme of VPP in spot market, carbon trading market, and green card market are established. On this basis, through the Shapley value and independent risk contribution theory in cooperative game theory, the quantitative… More > Graphic Abstract

    Optimal Operation of Virtual Power Plants Based on Revenue Distribution and Risk Contribution

  • Open Access

    REVIEW

    Understanding Adolescent Social Media Use: A Narrative Review of Motivations, Risk Factors, and Mental Health Implications

    Kyung-Hyun Suh1,*, Sung-Jin Chung1, Goo-Churl Jeong1, Kunho Lee1, Ji-Hyun Ryu2

    International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1829-1845, 2025, DOI:10.32604/ijmhp.2025.071879 - 31 December 2025

    Abstract Background: Adolescents increasingly engage with social media for connection, self-expression, and identity exploration. This growing digital engagement has raised concerns about its potential risks and mental health implications. Methods: This narrative review examines literature on adolescent social media use by exploring underlying motivations, risk and protective factors across personal, environmental, and digital domains, with a focus on mental health outcomes. Results: Individual vulnerabilities—such as low self-esteem, impulsivity, and poor sleep—interact with contextual factors like peer pressure and family conflict to elevate risks. Digital environments shaped by algorithmic feeds, feedback mechanisms, and curated content promote social comparison and More >

  • Open Access

    ARTICLE

    XGBoost-Based Active Learning for Wildfire Risk Prediction

    Hongrong Wang1,2, Hang Geng1,*, Jing Yuan1, Wen Zhang2, Hanmin Sheng1, Qiuhua Wang3, Xinjian Li4,5

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3701-3721, 2025, DOI:10.32604/cmes.2025.073513 - 23 December 2025

    Abstract Machine learning has emerged as a key approach in wildfire risk prediction research. However, in practical applications, the scarcity of data for specific regions often hinders model performance, with models trained on region-specific data struggling to generalize due to differences in data distributions. While traditional methods based on expert knowledge tend to generalize better across regions, they are limited in leveraging multi-source data effectively, resulting in suboptimal predictive accuracy. This paper addresses this challenge by exploring how accumulated domain expertise in wildfire prediction can reduce model reliance on large volumes of high-quality data. An active More >

  • Open Access

    ARTICLE

    Implementation and Evaluation of the Zero-Knowledge Protocol for Identity Card Verification

    Edward Danso Ansong*, Simon Bonsu Osei*, Raphael Adjetey Adjei

    Journal of Cyber Security, Vol.7, pp. 533-564, 2025, DOI:10.32604/jcs.2025.061821 - 11 December 2025

    Abstract The surge in identity fraud, driven by the rapid adoption of mobile money, internet banking, and e-services during the COVID-19 pandemic, underscores the need for robust cybersecurity solutions. Zero-Knowledge Proofs (ZKPs) enable secure identity verification by allowing individuals to prove possession of a National ID card without revealing sensitive information. This study implements a ZKP-based identity verification system using Camenisch-Lysyanskaya (CL) signatures, reducing reliance on complex trusted setup ceremonies. While a trusted issuer is still required, as assumed in this work, our approach eliminates the need for broader system-wide trusted parameters. We evaluate the system’s More >

  • Open Access

    ARTICLE

    Artificial Neural Network-Based Risk Assessment for Cardiac Implantable Electronic Device Complications

    Chih-Yin Chien1,2, Tsae-Jyy Wang1, Pei-Hung Liao1, Ying-Hsiang Lee3,4,5,*, Wei-Sho Ho6,7,*

    Congenital Heart Disease, Vol.20, No.5, pp. 601-612, 2025, DOI:10.32604/chd.2025.072431 - 30 November 2025

    Abstract Background: Cardiac implantable electronic devices (CIEDs) are essential for preventing sudden cardiac death in patients with cardiovascular diseases, but implantation procedures carry risks of complications such as infection, hematoma, and bleeding, with incidence rates of 3–4%. Previous studies have examined individual risk factors separately, but integrated predictive models are lacking. We compared the predictive performance and interpretability of artificial neural network (ANN) and logistic regression models to evaluate their respective strengths in clinical risk assessment. Methods: This retrospective study analyzed data from 180 patients who underwent cardiac implantable electronic device (CIED) implantation in Taiwan between 2017… More >

  • Open Access

    ARTICLE

    The Plateau Dilemma: Identifying Key Factors of Depression Risk among Middle-Aged and Older Chinese with Chronic Diseases

    Zhe He1, Yaning Zhang2,*

    International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1747-1768, 2025, DOI:10.32604/ijmhp.2025.070491 - 28 November 2025

    Abstract Background: Depression represents a significant global mental health burden, particularly among middle-aged and older Chinese with chronic diseases in high-altitude regions, where harsh environmental conditions and limited social support exacerbate mental health disparities. This paper aims to develop an interpretable machine learning prediction framework to identify the key factors of depression in this vulnerable population, thereby proposing targeted intervention measures. Methods: Utilizing data from the China Health and Retirement Longitudinal Study in 2020, this paper screened out and analyzed 2431 samples. Subsequently, Recursive Feature Elimination and Least Absolute Shrinkage and Selection Operator were applied to screen… More >

  • Open Access

    ARTICLE

    MITRE ATT&CK-Driven Threat Analysis for Edge-IoT Environment and a Quantitative Risk Scoring Model

    Tae-hyeon Yun1, Moohong Min2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2707-2731, 2025, DOI:10.32604/cmes.2025.072357 - 26 November 2025

    Abstract The dynamic, heterogeneous nature of Edge computing in the Internet of Things (Edge-IoT) and Industrial IoT (IIoT) networks brings unique and evolving cybersecurity challenges. This study maps cyber threats in Edge-IoT/IIoT environments to the Adversarial Tactics, Techniques, and Common Knowledge (ATT&CK) framework by MITRE and introduces a lightweight, data-driven scoring model that enables rapid identification and prioritization of attacks. Inspired by the Factor Analysis of Information Risk model, our proposed scoring model integrates four key metrics: Common Vulnerability Scoring System (CVSS)-based severity scoring, Cyber Kill Chain–based difficulty estimation, Deep Neural Networks-driven detection scoring, and frequency… More >

  • Open Access

    ARTICLE

    Influence Mechanism of Liquid Level on Oil Tank Structures and Damage Risk Prevention Based on Shell Theory

    Si-Kai Wang1, Ti-Cai Wang1, Di-Fei Yi2, Jia Rui3, Peng-Fei Cao4, Hua-Ping Wang1,5,*

    Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1411-1432, 2025, DOI:10.32604/sdhm.2025.070034 - 17 November 2025

    Abstract As a key storage facility, the structural safety of large oil tanks is directly related to the stable operation of the energy system. The static pressure caused by the change of liquid level is one of the main loads in the service process of storage tanks, which determines the structural deformation and damage risk. To explore the structural deformation properties under the change of liquid levels and provide a theoretical basis for the prevention and control of damage risk, this paper systematically analyzes the mechanical response of storage tanks under the pressures induced by different… More > Graphic Abstract

    Influence Mechanism of Liquid Level on Oil Tank Structures and Damage Risk Prevention Based on Shell Theory

  • Open Access

    ARTICLE

    Determination and assessing the role of serum calcium, vitamin D, ferritin, and uric acid levels on prostate cancer risk

    Abdulbari Bener1,2,*, Ünsal Veli Üstündağ3, Emir Barışık4, Cem Cahit Barışık5

    Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025

    Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

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