Aiyun Hu1, Sunli Cong1,*, Jian Ding2, Yao Cheng1, Enock Mpofu3
Computer Systems Science and Engineering, Vol.38, No.1, pp. 65-77, 2021, DOI:10.32604/csse.2021.016404
Abstract In the fed-batch cultivation of Saccharomyces cerevisiae, excessive glucose addition leads to increased ethanol accumulation, which will reduce the efficiency of glucose utilization and inhibit product synthesis. Insufficient glucose addition limits cell growth. To properly regulate glucose feed, a different evolution algorithm based on self-adaptive control strategy was proposed, consisting of three modules (PID, system identification and parameter optimization). Performance of the proposed and conventional PID controllers was validated and compared in simulated and experimental cultivations. In the simulation, cultivation with the self-adaptive control strategy had a more stable glucose feed rate and concentration, more stable ethanol concentration around the… More >
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