MARISA L. ZALLOCCHI*1, MARIA C. DAMASCO1, JUAN C. CALVO1,2, CARLOS P. LANTOS1, LAURA B. MATKOVIC1
BIOCELL, Vol.30, No.3, pp. 469-477, 2006, DOI:10.32604/biocell.2006.30.469
Abstract Prior to this work, we found that adrenal as well as extra-adrenal factors activate the response of renal 11ß-hydroxysteroid dehydrogenase 2 to stressful situations. These results -showing ways through which the organism hinders the pathological occupation of mineralocorticoid receptors by glucocorticoids leading to sodium retention and hypertension- prompted the present study on the nature of the above-mentioned extraadrenal factors. Serotonin was chosen because of its properties as a widely distributed neurohormone, known to interact with glucocorticoids at many sites, also exhibiting increased levels and effects under stressful situations. We studied serotonin effects on 11ß-hydroxysteroid dehydrogenase 2 activity in a cell… More >
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