Yueting Li^1,*, Ning Guo¹, Zhongxuan Yang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09970

Abstract The rheological behavior of fluid-particle suspensions affects the flow dynamics of natural processes such as lavas, flow-type landslides and sediment transport. This study presents results of fully resolved simulations of monodisperse non-Brownian suspensions in a Couette flow using the smoothed particle hydrodynamics (SPH) method coupled with discrete element method (DEM), which allows for simulation of arbitrary-shaped particles. Several benchmark tests have been conducted to verify the reliability of the method. Two density ratios are considered in the study, i.e., 2.65 and 10, with the average particle area fraction varying from 14% to 47% and particle Reynolds number varying from 0.15… More >

Liang Ce, Yongchen Pan^*

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.6, pp. 1115-1128, 2020, DOI:10.32604/fdmp.2020.010829

Abstract Two flow cases for scaled high speed train models with different length are numerically analyzed in the framework of the improved delayed detachededdy simulation model. Specific attention is paid to the shear flows and related mechanisms in the near turbulent wake created by these moving models. In particular, a comparative analysis is made on the distributions of turbulent kinetic energy (TKE) and turbulence production (TP) in planes perpendicular to the streamwise direction. The numerical results suggest that, in the wake region very close to the tail, significant TKE and TP can be ascribed to the dynamic interaction between powerful eddies… More >

Ning Li^{1, 2, 3}, Xiao Zhang^{1, 2}, Peiwen Li^{1, 2}, Hao Yang^{1, 2}, Chunfang Tong^{1, 2}, Shouqin Lü^{1, 2}, Yan Zhang^{1, 2}, Zhiyi Ye³, Jun Pan^{3, *}, Mian Long^{1, 2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 263-279, 2018, DOI:10.31614/cmes.2018.04079

Abstract Neutrophil (PMN) accumulation on liver sinusoidal endothelial cells (LSECs) is crucial to pathogen clearance and tissue damage in the liver sinusoids and controlled by a series of adhesion molecules expressed on the surface of PMNs and LSECs. The role of lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in this process is still contentious. Here we compared the dynamic force spectra of the binding of β2 integrin to intercellular adhesion molecule-1 (ICAM-1) on LSECs using atomic force microscopy (AFM) and performed free and steered molecular dynamics (MD) simulations to analyze their structural bases of LFA-1- or Mac-1-I-domain and ICAM-1-D1 or… More >

Virginia Aragon Sanabria¹, Cheng Dong^*

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 1-19, 2018, DOI:10.3970/mcb.2018.015.001

Abstract Endothelial barrier function is critical for tissue homeostasis throughout the body. Disruption of the endothelial monolayer leads to edema, vascular diseases and even cancer metastasis among other pathological conditions. Breakdown of the endothelial barrier integrity triggered by cytokines (e.g.IL-8,IL-1β) and growth factors (e.g.VEGF) is well documented. However, endothelial cells are subject to major biomechanical forces that affect their behavior. Due to their unique location at the interface between circulating blood and surrounding tissues, endothelial cells experience shear stress, strain and contraction forces. More than three decades ago, it was already appreciated that shear flow caused endothelial cells alignment in the… More >

Meghan H. Hoskins^*, Cheng Dong^∗,†

Molecular & Cellular Biomechanics, Vol.3, No.2, pp. 79-88, 2006, DOI:10.3970/mcb.2006.003.079

Abstract It has been determined previously that polymorphonuclear leukocytes, or PMNs, can facilitate melanoma cell extravasation through the endothelium under shear conditions [1,2]. The interactions between melanoma cells and PMNs are mediated by the β₂-integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. In this study, the kinetics of these interactions was studied using a parallel plate flow chamber. The dissociation rates were calculated under low force conditions for ICAM-1 interactions with both β₂-integrins, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), together and separately by using functional blocking antibodies on PMNs. The kinetics of PMNs stimulated with IL-8 was… More >

Wenzhong Tang¹, Suresh G. Advani¹

CMES-Computer Modeling in Engineering & Sciences, Vol.25, No.3, pp. 149-164, 2008, DOI:10.3970/cmes.2008.025.149

Abstract In this paper, a method for studying nanotube dynamics in simple shear flow was developed. A nanotube was described as a flexible fiber with a sphere-chain model. The forces on the nanotube were obtained by molecular dynamics simulations. The motion of the nanotube in simple shear flow was tracked by the flexible fiber dynamics method [Tang and Advani (2005)]. The viscosity of dilute nanotube suspensions was calculated based on the nanotube dynamics, and the effects of the aspect ratio and initial curvature of the nanotube on suspension viscosity are explored and discussed. More >

Wenzhong Tang¹, Suresh G. Advani¹

CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.2, pp. 165-176, 2005, DOI:10.3970/cmes.2005.008.165

Abstract An optimization method is proposed to simulate the motion of long flexible fibers in shear flow. The fiber is modeled as spheres connected by massless rigid rods and ball-socket joints. The optimization method is mathematically justified and used to obtain the position of a fiber at the next time step from its current position. Results for a single fiber in simple shear flow agree well with those reported in the literature. The usefulness of the method is demonstrated by simulating the motion of two interactive fibers subjected to shear flow field, and by studying the viscosity of dilute suspensions of… More >

R. Abdeljabar¹, F. Onofri², M.J. Safi¹

FDMP-Fluid Dynamics & Materials Processing, Vol.4, No.4, pp. 245-254, 2008, DOI:10.3970/fdmp.2008.004.245

Abstract This paper focuses on the mechanisms of convective instability in a stable salty gradient layer (i.e. an interfacial salty layer). This layer is assumed to be initially confined between two homogeneous liquid layers: a lower layer composed of salty water of 5wt% concentration and an upper layer composed of distilled water. The mechanisms underlying the interfacial salty layer's instability are depicted experimentally using a PIV technique and via measurements of concentration and temperature. It is found that in addition to the effect of double-diffusion across the interfacial salty layer, different forms of Kelvin-Helmholtz instability occur at different locations:\newline i. At… More >