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    Biomechanical Aspects of the Auto-digestion Theory

    Geert W. Schmid-Schönbein*

    Molecular & Cellular Biomechanics, Vol.5, No.2, pp. 83-96, 2008, DOI:10.3970/mcb.2008.005.083

    Abstract Increasing evidence suggests that most cardiovascular diseases, tumors and other ailments are associated with an inflammatory cascade. The inflammation is accompanied by activation of cells in the circulation and fundamental changes in the mechanics of the microcirculation, expression of pro-inflammatory genes and downregulation of anti-inflammatory genes, attachment of leukocytes to the endothelium, elevated permeability of the endothelium, and many other events. The evidence has opened great opportunities for medicine to develop new anti-inflammatory interventions. But it also raises a fundamental question: What is the origin of inflammation? I will discuss a basic series of studies that was designed to explore… More >

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