HUIFANG CHEN1,2, XIAOYING ZHOU2, ZONGHONG LONG2, XIANGLONG TANG2, HONG LI2,*
BIOCELL, Vol.44, No.3, pp. 371-379, 2020, DOI:10.32604/biocell.2020.08893
Abstract UQCRC1 is one of the 10 mitochondrial complex III subunits, this protein has a role in energy metabolism,
myocardial protection, and neurological diseases. The upstream mechanism of the UQCRC1 protective effect on
cardiomyocytes is currently unavailable. In order to explore the upstream molecules of UQCRC1 and elucidate the
protective mechanism of UQCRC1 on cardiomyocytes in more detail, we focused on the nuclease-sensitive elementbinding protein 1 (YB-1). We hypothesized YB-1 acts as an upstream regulatory molecule of UQCRC1. This study
found that YB-1 RNAi significantly reduces the expression of the UQCRC1 protein level (p < 0.05) and obviously
decreases the mitochondrial… More >
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