CUIXIA CHEN1*, LINGLING CUI2, XIN SHANG2, XIANLU ZENG2
BIOCELL, Vol.34, No.2, pp. 57-64, 2010, DOI:10.32604/biocell.2010.34.057
Abstract L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited… More >
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