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    Screen for autophagy-related biomarkers in osteoarthritis based on bioinformatic analysis


    BIOCELL, Vol.48, No.2, pp. 339-351, 2024, DOI:10.32604/biocell.2023.047044

    Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These… More >

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