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  • Open Access

    REVIEW

    Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Meta-Analysis of All Randomized Clinical Trials with Subgroup Analysis by Patient Profile

    Carlo Ronsini1,*, Giuseppe Cucinella1, Maria Cristina Solazzo1, Mariano Catello Di Donna1, Cono Scaffa1, Stefano Cianci2, Manuela Ludovisi3, Sandro Pignata4, Vito Chiantera1

    Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074934 - 22 April 2026

    Abstract Background: The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated. While primary debulking surgery (PDS) has been considered the standard approach, recent randomized trials have questioned its survival advantage over neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The study aimed to systematically evaluate phase III randomized controlled trials comparing PDS and NACT. Methods: Following PRISMA guidelines (PROSPERO ID 1169057), PubMed and Scopus were systematically searched in October 2025 for phase III randomized clinical trials evaluating cytoreductive strategies in ovarian carcinoma. Only full-text English studies reporting overall survival (OS)… More >

  • Open Access

    CASE REPORT

    Management of retained bullet fragments from posterior urethra after gunshot wound: a case report

    Sarah M. Kodres–O’Brien*, Mackenzie Koellermeier, Nayan Shah, Peter Langenstroer

    Canadian Journal of Urology, Vol.33, No.2, pp. 471-476, 2026, DOI:10.32604/cju.2025.069550 - 20 April 2026

    Abstract Background: Retained bullet fragments in the genitourinary tract following gunshot wound is rare and require removal. Case Description: We present the case of a retained bullet in the prostate following a gunshot wound to the pelvis, which was endoscopically removed. A urethral catheter and suprapubic tube were placed. The patient then had migration of a second bullet fragment into the prostatic urethra six weeks later, requiring open removal. Conclusions: This case shows that several approaches can be considered to remove retained bullet fragments from the urinary tract. Furthermore, access to the bladder via a suprapubic tube More >

  • Open Access

    ARTICLE

    Expert Consensus on Right Axillary Incision Approach for Open-Heart Surgery in Congenital Heart Disease

    Xuming Mo1,*, Taibing Fan2,*, Zhongdong Hua3,*, Christoph Haller4, Shinichiro Oda5, Shuhua Luo6, Weijie Liang2, Yuzhong Yang1, Huaipu Liu3, Nianguo Dong7, Shoujun Li8, Xinxin Chen9, Jimei Chen10, Hao Zhang11, Qiang Shu12, Haibo Zhang11, Quansheng Xing13, Jinghao Zheng11, Xiaofeng Li14, Teng Ming15, Qi An16, Ping Wen17, Qiang Wang18, Jirong Qi1, Huiwen Chen11, Shusheng Wen19, Rui Chen20, Ming Ye21, Keming Yang8, Minhua Fang22, Caixia Liu23, Ke Lin16, Zhongshi Wu24, Xiangming Fan12, Zhengxia Pan25, Yiqun Ding26, Ming’an Pi27, Xin Li28, Yong Zou29, Shuguang Tao30, Renwei Chen31, Li Ma9, Libing Zhang32, Tao You33, Dongshan Liao34, Cheng Zhou35, Hongxin Li36, Gengxu Zhou37, Chunhu Gu38, Zhiqiang Li39, Yonggang Li25, Hui Zhang40, Xiaomin He11, Yanan Lu11, Haifa Hong41, Benqing Zhang8, Li Gong27, Jiafeng Qi42, Song Bai39, Yuhang Liu43, Tianli Zhao24, Cardiothoracic Surgery Group, Pediatric Surgery Branch of Chinese Medical Doctor Association, Cardiac Surgery Group, Pediatric Surgery Branch of Chinese Medical Association, the Asian Association for Pediatric and Congenital Heart Surgery

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.077974 - 31 March 2026

    Abstract Congenital heart disease (CHD) is a common birth defect in children, and surgical intervention is the primary treatment. The traditional standard median sternotomy (MS) has drawbacks such as significant trauma and obvious scarring. The right axillary incision (RAI) has gradually become a conventional approach due to its advantages of preserving thoracic cage integrity, small incision size, rapid recovery, and hidden scarring. However, there is currently a lack of relevant guidelines and consensus for its application. This consensus adopts the international Delphi process, systematically searching domestic and foreign literature on CHD from 1982 to 2024. It… More >

  • Open Access

    ARTICLE

    Analysis of Relevant Factors Associated with Postoperative Recovery after Anomalous Origin of the Left Coronary Artery from Pulmonary Artery Surgery in Children

    Jia Yuan1,2,#, Yanxing Lv2,#, Xinyuan Ding3, Yunyi Zeng1, Li Ma4, Hang Yang1, Lin Jiang1, Kamil Bildebayev5, Boiko Yuliya Nikolaevna5, Na Zhou1,*

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.076648 - 31 March 2026

    Abstract Backgorund: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly of coronary artery anatomy, usually diagnosed in infancy, but adults may also be affected by this deformity. Objectives: The aim of this study is to examine long-term outcomes in patients with ALCAPA and analyze the relevant factors influencing postoperative outcomes. Methods: The records of patients with ALCAPA admitted from January 2015 to December 2024 were retrospectively reviewed. Clinical data of the patients were retrieved from the records. The follow-up data included mortality rates and complications. Kaplan-Meier survival curves were… More >

  • Open Access

    CASE REPORT

    Progressive Right Ventricular Outflow Tract Obstruction Following Perimembranous VSD Closure with Lifetech™ Konar-Multifunctional Occluder (MFO) Device: A Rare Case of Valve–Device Interaction

    Mete Han Kizilkaya1, Boran Cakan2,3,*, Mehmet Bicer4, Ender Odemis1,5

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.074189 - 31 March 2026

    Abstract Background: Transcatheter closure of perimembranous ventricular septal defects (pmVSDs) with Lifetech™ Konar-Multifunctional Occluder (MFO) has demonstrated high procedural success and safety. However, long-term complications due to valve–device interaction are rarely reported. We describe a pediatric patient who developed progressive right ventricular outflow tract (RVOT) obstruction and severe tricuspid regurgitation 20 months after MFO closure, highlighting mechanisms, management, and outcomes. Case Description: A 13-year-old girl underwent successful MFO closure of a 6-mm pmVSD. Early follow-up showed trivial tricuspid regurgitation and mild subpulmonic stenosis. Pre-procedural imaging revealed right ventricular hypertrophy caused by long-standing jet-related turbulence from the pmVSD, with… More >

  • Open Access

    CASE REPORT

    Late Embolization of a Ductal Stent in Pulmonary Atresia with Intact Ventricular Septum Successfully Managed by Urgent Central Shunt Reconstruction: A Case Report

    Ricardo Garcia-Mora1, Gunther Hernández-Morales2, Miguel Ángel Chagolla-Santillán3, Iliana Acevedo-Bañuelos3, Jorge Luis Cervantes-Salazar4, Edel Rafael Rodea-Montero5,*

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.071470 - 31 March 2026

    Abstract We report a full-term newborn with pulmonary atresia with an intact ventricular septum who developed acute hypoxemia after ductal stent embolization. Emergency surgery was performed to remove the stent and create a central systemic-to-pulmonary shunt using a 3.5 mm GORE-TEX® graft via a modified Gates, Laks, and Johnson technique. Postoperative recovery was favorable. At 24 months, the shunt remained patent with adequate pulmonary artery growth. This case underscores prompt surgical rescue and supports central shunting as an effective mid-term solution. More >

  • Open Access

    REVIEW

    Surgery Alone Treatment vs. Surgery with Adjuvant Therapy for Laryngeal Mucoepidermoid Cancer: A Systematic Review

    Francesco Chiari1,*, Giovanni Motta2, Daria Maria Filippini3, Claudio Donadio Caporale1, Pierre Guarino1

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073086 - 23 March 2026

    Abstract Objective: Mucoepidermoid carcinoma (MEC) of the larynx is an extremely rare malignancy, accounting for less than 1% of primary laryngeal tumors. The optimal role of adjuvant therapy, particularly radiotherapy (RT), remains unclear due to limited evidence. This systematic review aimed to evaluate oncologic outcomes and the impact of adjuvant treatment in patients with early- and advanced-stage laryngeal MEC. Methods: A systematic literature search was performed according to PRISMA 2020 guidelines in PubMed/Embase, Scopus, and Cochrane for studies published up to 31 July 2025. Results: Twenty-two studies, encompassing 55 patients, were included. Early-stage (T1–T2) patients (n =… More >

  • Open Access

    REVIEW

    Artificial intelligence assisted 3D in the robotic urooncology? A systematic review and narrative synthesis of current applications, challenges and future directions

    Bara Barakat1,*, Bilal Al-Absi1, Boris Hadaschik2, Christian Rehme2, Samer Schakaki3, Joerg Bauer1

    Canadian Journal of Urology, Vol.33, No.1, pp. 105-116, 2026, DOI:10.32604/cju.2026.071284 - 28 February 2026

    Abstract Background: Artificial intelligence (AI)-assisted three-dimensional (3D) surgical platforms, integrated with augmented reality, have the potential to improve intraoperative anatomical recognition and provide surgeons with an immersive, dynamic operating environment during uro-oncological procedures. This review aims to examine the current applications of AI in robotic uro-oncology, with a particular focus on its role in facilitating intraoperative navigation during complex surgeries. Methods: A systematic literature search was performed across PubMed, the National Library of Medicine, MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Google Scholar to identify relevant studies published up to July 2025.… More >

  • Open Access

    ARTICLE

    Is postoperative routine thoracic imaging necessary to detect thoracic complications in patients undergoing supracostal mini percutaneous nephrolithotomy (m-PCNL) surgery?

    Abdullah Esmeray, Huseyin Burak Yazili*, Mucahit Gelmis, Nazim Furkan Gunay, Caglar Dizdaroglu, Faruk Ozgor, Yasar Pazir, Ufuk Caglar

    Canadian Journal of Urology, Vol.33, No.1, pp. 165-171, 2026, DOI:10.32604/cju.2025.069657 - 28 February 2026

    Abstract Objectives: Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity remains controversial. This study aimed to assess the necessity of routine postoperative thoracic imaging for detecting pulmonary complications in patients undergoing supracostal mini percutaneous nephrolithotomy (m-PCNL) surgery. Methods: A retrospective analysis was conducted on data from patients who underwent supracostal m-PCNL between 2017 and 2022 in a tertiary center. Excluding patients under 18, with kidney/skeletal anomalies, or active thoracic disease, 112 eligible patients were included. Patients were… More >

  • Open Access

    ARTICLE

    Uretero-enteric strictures after cystectomy: revealing the modifiable risk factors

    Abdelkader Akkad, Franck Bruyere, Ali Bourgi*

    Canadian Journal of Urology, Vol.33, No.1, pp. 155-163, 2026, DOI:10.32604/cju.2025.069546 - 28 February 2026

    Abstract Objectives: Uretero-enteric strictures are feared complications following cystectomy. Despite surgical advancements, particularly the rise of robot-assisted approaches, the risk factors associated with these strictures remain poorly defined. This study aimed to identify the risk factors associated with uretero-enteric anastomotic strictures after cystectomy, according to the surgical approach and type of urinary diversion (extracorporeal vs. intracorporeal). Methods: We conducted a single-center retrospective study including 340 patients who underwent cystectomy between 2016 and 2024 at Tours University Hospital. Clinical, biological, perioperative, and postoperative data were analyzed. The occurrence of a uretero-ileal anastomotic stricture was defined radiologically by… More >

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