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  • Open Access

    REVIEW

    Induction Therapy Followed by Surgery in Advanced Thymic Epithelial Tumors: A 20-Year Systematic Review and Meta-Analysis

    Giovanni Leuzzi1,*, Michele Ferrari1, Federica Sabia1, Alessandro Pardolesi1, Alessia Stanzi1, Claudia Proto2, Giuseppe Lo Russo2, Arsela Prelaj2, Monica Ganzinelli2, Matteo Calderoni1, Clarissa Uslenghi1, Ugo Pastorino3, Piergiorgio Solli1

    Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.077158 - 16 July 2026

    Abstract Backgrounds: Despite the availability of multimodal strategies, no universally accepted guidelines exist for the management of advanced Thymic Epithelial Tumors (TETs), particularly in locally advanced thymomas. The aim of this study was to evaluate the oncological and surgical outcomes of induction therapy (IT) followed by surgery in patients with Masaoka–Koga stage III–IVA TETs. To this end, we conducted a systematic review and meta-analysis assessing surgical-pathological and survival outcomes. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials was performed.… More > Graphic Abstract

    Induction Therapy Followed by Surgery in Advanced Thymic Epithelial Tumors: A 20-Year Systematic Review and Meta-Analysis

  • Open Access

    ARTICLE

    Same-day surgical cancellations in pediatric urology: identifying trends for quality improvement

    Tyler Overholt Daniel1,*, David Thole2, Randy Casals3, Anthony Atala3, Steve Hodges3, Marc Colaco3

    Canadian Journal of Urology, Vol.33, No.3, pp. 693-698, 2026, DOI:10.32604/cju.2026.074059 - 29 June 2026

    Abstract Objectives: Day of surgery cancellations present several workflow challenges that result in delay of care for patients and revenue loss for physicians. This study aimed to further understand same-day pediatric urology surgical cancellations, and the authors assessed identifiable trends for quality improvement over a one-year time period. Methods: Same-day surgical cancellations were prospectively identified at a single tertiary care center, Atrium Health Wake Forest Baptist, from 01 October 2022 to 30 September 2023. Reasons for cancellation were recorded per the parent/legal guardian and categorized as an avoidable or unavoidable cause. Demographic data, surgical rescheduling, and… More >

  • Open Access

    ARTICLE

    An outbreak of multidrug-resistant Pseudomonas aeruginosa infections following flexible ureteroscopic stone removal

    Sin Woo Lee*, Seung-Kwon Choi

    Canadian Journal of Urology, Vol.33, No.3, pp. 527-535, 2026, DOI:10.32604/cju.2025.073355 - 29 June 2026

    Abstract Background: Postoperative infections are an emerging concern in endourology. This study reports an outbreak of urinary tract infections associated with Pseudomonas aeruginosa (PA) in patients who underwent stone removal surgery using flexible ureteroscopy (FURS) at Seoul Medical Center. Methods: Between August and December 2024, five patients who underwent FURS performed by the same surgeon developed postoperative febrile episodes requiring further treatment. Urine cultures from four patients revealed an outbreak of multidrug-resistant PA, prompting environmental cultures and an inspection of the instrument reprocessing procedures led by the hospital’s infection control department. Results: Although PA was not isolated from… More >

  • Open Access

    ARTICLE

    Optimizing postoperative pain relief with a novel technique: intraluminal lidocaine administration during retrograde intrarenal surgery

    Sezgin Yeni1,*, Hakan Kilicarslan2, Bertan Tanrıbuyurdu2, Levent Turan2, Hatice Ortac3, Onur Kaygisiz2

    Canadian Journal of Urology, Vol.33, No.3, pp. 635-642, 2026, DOI:10.32604/cju.2026.072974 - 29 June 2026

    Abstract Objectives: Retrograde intrarenal surgery (RIRS) has become an increasingly preferred minimally invasive option for the management of kidney stones. However, postoperative pain remains a major clinical concern that may adversely affect patient comfort and recovery. This study aimed to evaluate whether intraluminal administration of lidocaine at the end of RIRS could effectively reduce postoperative pain and analgesic requirements. Methods: A total of 61 patients who underwent RIRS between March and July 2024 were evaluated. Four patients were excluded due to residual stones, and five due to a history of cardiac arrhythmia, leaving 52 patients for… More >

  • Open Access

    ARTICLE

    Clinical evaluation and related factor analysis of intrarenal pressure using a Chinese-made disposable pressure-measuring flexible ureteroscope

    Yubao Liu, Haifeng Song, Zheng Xu, Weiguo Hu, Bo Xiao, Gang Zhang, Boxing Su, Bixiao Wang, Jianxing Li*

    Canadian Journal of Urology, Vol.33, No.3, pp. 685-692, 2026, DOI:10.32604/cju.2025.070417 - 29 June 2026

    Abstract Objective: The pressure fluctuations during retrograde intrarenal surgery (RIRS) can cause related complications, so precise monitoring and control of intrarenal pressure (IRP) play an important role. This study aimed to assess the clinical value of a Chinese-made disposable pressure-measuring flexible ureteroscope in monitoring IRP during RIRS for upper urinary tract stones <2 cm, and analyze factors affecting IRP. Methods: In this prospective single-arm study, 35 patients (38 renal units) underwent RIRS. Mean age was 42.3 ± 6.1 years, body mass index (BMI) 24.2 ± 2.6 kg/m², and maximum stone diameter 1.6 ± 0.4 cm. Stones… More >

  • Open Access

    REVIEW

    Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Meta-Analysis of All Randomized Clinical Trials with Subgroup Analysis by Patient Profile

    Carlo Ronsini1,*, Giuseppe Cucinella1, Maria Cristina Solazzo1, Mariano Catello Di Donna1, Cono Scaffa1, Stefano Cianci2, Manuela Ludovisi3, Sandro Pignata4, Vito Chiantera1

    Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074934 - 22 April 2026

    Abstract Background: The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated. While primary debulking surgery (PDS) has been considered the standard approach, recent randomized trials have questioned its survival advantage over neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The study aimed to systematically evaluate phase III randomized controlled trials comparing PDS and NACT. Methods: Following PRISMA guidelines (PROSPERO ID 1169057), PubMed and Scopus were systematically searched in October 2025 for phase III randomized clinical trials evaluating cytoreductive strategies in ovarian carcinoma. Only full-text English studies reporting overall survival (OS)… More >

  • Open Access

    CASE REPORT

    Management of retained bullet fragments from posterior urethra after gunshot wound: a case report

    Sarah M. Kodres–O’Brien*, Mackenzie Koellermeier, Nayan Shah, Peter Langenstroer

    Canadian Journal of Urology, Vol.33, No.2, pp. 471-476, 2026, DOI:10.32604/cju.2025.069550 - 20 April 2026

    Abstract Background: Retained bullet fragments in the genitourinary tract following gunshot wound is rare and require removal. Case Description: We present the case of a retained bullet in the prostate following a gunshot wound to the pelvis, which was endoscopically removed. A urethral catheter and suprapubic tube were placed. The patient then had migration of a second bullet fragment into the prostatic urethra six weeks later, requiring open removal. Conclusions: This case shows that several approaches can be considered to remove retained bullet fragments from the urinary tract. Furthermore, access to the bladder via a suprapubic tube More >

  • Open Access

    ARTICLE

    Expert Consensus on Right Axillary Incision Approach for Open-Heart Surgery in Congenital Heart Disease

    Xuming Mo1,*, Taibing Fan2,*, Zhongdong Hua3,*, Christoph Haller4, Shinichiro Oda5, Shuhua Luo6, Weijie Liang2, Yuzhong Yang1, Huaipu Liu3, Nianguo Dong7, Shoujun Li8, Xinxin Chen9, Jimei Chen10, Hao Zhang11, Qiang Shu12, Haibo Zhang11, Quansheng Xing13, Jinghao Zheng11, Xiaofeng Li14, Teng Ming15, Qi An16, Ping Wen17, Qiang Wang18, Jirong Qi1, Huiwen Chen11, Shusheng Wen19, Rui Chen20, Ming Ye21, Keming Yang8, Minhua Fang22, Caixia Liu23, Ke Lin16, Zhongshi Wu24, Xiangming Fan12, Zhengxia Pan25, Yiqun Ding26, Ming’an Pi27, Xin Li28, Yong Zou29, Shuguang Tao30, Renwei Chen31, Li Ma9, Libing Zhang32, Tao You33, Dongshan Liao34, Cheng Zhou35, Hongxin Li36, Gengxu Zhou37, Chunhu Gu38, Zhiqiang Li39, Yonggang Li25, Hui Zhang40, Xiaomin He11, Yanan Lu11, Haifa Hong41, Benqing Zhang8, Li Gong27, Jiafeng Qi42, Song Bai39, Yuhang Liu43, Tianli Zhao24, Cardiothoracic Surgery Group, Pediatric Surgery Branch of Chinese Medical Doctor Association, Cardiac Surgery Group, Pediatric Surgery Branch of Chinese Medical Association, the Asian Association for Pediatric and Congenital Heart Surgery

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.077974 - 31 March 2026

    Abstract Congenital heart disease (CHD) is a common birth defect in children, and surgical intervention is the primary treatment. The traditional standard median sternotomy (MS) has drawbacks such as significant trauma and obvious scarring. The right axillary incision (RAI) has gradually become a conventional approach due to its advantages of preserving thoracic cage integrity, small incision size, rapid recovery, and hidden scarring. However, there is currently a lack of relevant guidelines and consensus for its application. This consensus adopts the international Delphi process, systematically searching domestic and foreign literature on CHD from 1982 to 2024. It… More >

  • Open Access

    ARTICLE

    Analysis of Relevant Factors Associated with Postoperative Recovery after Anomalous Origin of the Left Coronary Artery from Pulmonary Artery Surgery in Children

    Jia Yuan1,2,#, Yanxing Lv2,#, Xinyuan Ding3, Yunyi Zeng1, Li Ma4, Hang Yang1, Lin Jiang1, Kamil Bildebayev5, Boiko Yuliya Nikolaevna5, Na Zhou1,*

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.076648 - 31 March 2026

    Abstract Backgorund: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly of coronary artery anatomy, usually diagnosed in infancy, but adults may also be affected by this deformity. Objectives: The aim of this study is to examine long-term outcomes in patients with ALCAPA and analyze the relevant factors influencing postoperative outcomes. Methods: The records of patients with ALCAPA admitted from January 2015 to December 2024 were retrospectively reviewed. Clinical data of the patients were retrieved from the records. The follow-up data included mortality rates and complications. Kaplan-Meier survival curves were… More >

  • Open Access

    CASE REPORT

    Progressive Right Ventricular Outflow Tract Obstruction Following Perimembranous VSD Closure with Lifetech™ Konar-Multifunctional Occluder (MFO) Device: A Rare Case of Valve–Device Interaction

    Mete Han Kizilkaya1, Boran Cakan2,3,*, Mehmet Bicer4, Ender Odemis1,5

    Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.074189 - 31 March 2026

    Abstract Background: Transcatheter closure of perimembranous ventricular septal defects (pmVSDs) with Lifetech™ Konar-Multifunctional Occluder (MFO) has demonstrated high procedural success and safety. However, long-term complications due to valve–device interaction are rarely reported. We describe a pediatric patient who developed progressive right ventricular outflow tract (RVOT) obstruction and severe tricuspid regurgitation 20 months after MFO closure, highlighting mechanisms, management, and outcomes. Case Description: A 13-year-old girl underwent successful MFO closure of a 6-mm pmVSD. Early follow-up showed trivial tricuspid regurgitation and mild subpulmonic stenosis. Pre-procedural imaging revealed right ventricular hypertrophy caused by long-standing jet-related turbulence from the pmVSD, with… More >

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