Masataka Ogiso^1,2, Kei Inai^1,*, Morio Shoda², Nobuhisa Hagiwara², Hisashi Sugiyama¹

Congenital Heart Disease, Vol.15, No.6, pp. 483-493, 2020, DOI:10.32604/CHD.2020.013058 - 02 November 2020

Abstract Background: Pulmonary hypertension (PH) is one of the complications that can occur after the atrial switch procedure for transposition of the great arteries (TGA). This study aimed to assess the characteristics and prognosis of late-onset PH after the atrial switch procedure using catheterization data. Methods and Results: We retrospectively identified 40 patients with TGA after the atrial switch procedure that underwent catheterization between April 2007 and March 2020. Eligible patients were divided into two groups based on PH presence (PH group, n = 13 [33%]; non-PH group, n = 27 [67%]). Adverse events were defined as cardiac… More >

Yoann Perreux¹, Marie Alexandre Chaix², Anna Kamp³, François-Pierre Mongeon², Magali Pham², Loïc Boussel¹, Roland Henaine¹, Annie Dore², Blandine Mondésert², Sylvie Di-Filippo¹, Paul Khairy², Francis Bessiere^1,*

Congenital Heart Disease, Vol.15, No.6, pp. 473-482, 2020, DOI:10.32604/CHD.2020.013032 - 02 November 2020

Abstract Sudden cardiac death and heart failure are well known long-term complications after atrial switch for D-transposition of the great arteries (D-TGA). Right systemic ventricular dysfunction is common and myocardial ischemia has been implicated as a putative mechanism for sudden death, with coronary anomalies prevalent in 30% of cases. We sought to assess an association between adverse events and coronary anomalies in patients with D-TGA and atrial switch surgery. An observational study was conducted in 3 tertiary centers (Montreal Heart Institute, Canada, Nationwide Children’s hospital, Chicago, USA and Hopital cardiologique Louis Pradel de Lyon, France). Adults… More >

Domenico Sirico¹, Biagio Castaldi^1,*, Giuseppe Tarantini², Giovanni Di Salvo¹

Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863 - 02 November 2020

Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically More >

Francisco Javier Ruperti-Repilado^1,#,*, Magalie Ladouceur^2,#, Pastora Gallego³, Laura Dos⁴, Joaquin Rueda Soriano⁵, Berto Bouma⁶, Harald Gabriel⁷, Markus Schwerzmann¹, Judith Bouchardy^8,9, Daniel Tobler^10,#, Matthias Greutmann^11,#

Congenital Heart Disease, Vol.15, No.5, pp. 309-338, 2020, DOI:10.32604/CHD.2020.012599 - 23 September 2020

Abstract Background: Long-term outcomes in adults with prior arterial switch operation (ASO) have not yet been well defined. The aim of this study is to elucidate incidence and predictors of adverse cardiac outcomes in a prospectively followed cohort of adults after their ASO. Methods: The comprehensive longterm follow up of adults with ASO is a project within the European collaboration for prospective outcome research in congenital heart disease (EPOCH). It is designed as a prospective, international multicenter cohort study. Consecutive patients (age ≥ 16 years) with prior ASO will be included at 11 European tertiary care centers.… More >

Yu Wang¹, Chen Liu¹, Lei Wang², Lihua Zhu^{1, *}

CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 419-432, 2020, DOI:10.32604/cmc.2020.010911 - 23 July 2020

Abstract The internal structure of the inertial measurement unit (IMU) in active state is easily damaged in the high overload environment. So that the IMU is usually required to be powered within the disappearance of the high overload. In this paper, a mechanical switch is designed to enable the IMU based on the analysis of the impact of high overload on the power-supply circuit. In which, parameters of mechanical switch are determined through theoretical calculation and data analysis. The innovation of the proposed structure lies in that the mechanical switch is triggered through the high overload More >

Ylenia Bartolacelli^*, Giulia Bragantini

Congenital Heart Disease, Vol.15, No.2, pp. 59-68, 2020, DOI:10.32604/CHD.2020.011448 - 23 June 2020

Abstract Objective: The objective of this study was to assess left ventricle (LV) function and remodeling by three-dimensional echocardiography (3DE) in patients who underwent arterial switch procedure (ASO) for transposition of great arteries (TGA) in long-term follow-up. Methods and Results: We studied 54 asymptomatic patients (39 male) who have undergone single-stage ASO for TGA, aged 13.7 ± 4.7 years, with a normal LV ejection fraction (EF), compared to healthy peers. We evaluated LV volume and function in asymptomatic patients with normal ejection fraction by 3DE. All patients had normal EF, measured by modified Simpson’s method (mean 60.9 ±… More >

Yueqi Hou¹, Xiaolong Liang^{1, 2}, Lyulong He¹, Jiaqiang Zhang^{1, *}, Jie Zhu³, Baoxiang Ren³

CMC-Computers, Materials & Continua, Vol.62, No.3, pp. 1335-1349, 2020, DOI:10.32604/cmc.2020.06869

Abstract Consensus control of multi-agent systems has attracted compelling attentions from various scientific communities for its promising applications. This paper presents a discrete-time consensus protocol for a class of multi-agent systems with switching topologies and input constraints based on distributed predictive control scheme. The consensus protocol is not only distributed but also depends on the errors of states between agent and its neighbors. We focus mainly on dealing with the input constraints and a distributed model predictive control scheme is developed to achieve stable consensus under the condition that both velocity and acceleration constraints are included More >

Yasser Bagheri^1,2,3, Fateme Babaha⁴, Reza Falak^1,2, Reza Yazdani³, Gholamreza Azizi⁵, Maryam Sadri¹, Hassan Abolhassani^3,6, Mehdi Shekarabi^1,2, Asghar Aghamohammadi³

European Cytokine Network, Vol.30, No.3, pp. 107-113, 2019, DOI:10.1684/ ecn.2019.0434

Abstract Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); however, the underlying mechanisms remain to be fully elucidated. The objective of this study was to investigate the TGF-β response during B stimulation of human B cells by IL-10. Methods: Pan B cells of healthy donors were negatively purified by a magnetic cell separation technique. B cells were cultured… More >

Laleh Sharifi^1,2, Asghar Aghamohammadi^1,3, Nima Rezaei^3,4,5, Reza Yazdani¹, Farhad Rezaei⁶, Saied Bokaie⁷, Farzaneh Tofighi Zavareh^2,8, Fatemeh Kiaee³, Ali N. Kamali⁹, Gholamreza Azizi¹⁰, Abbas Mirshafiey^1,8

European Cytokine Network, Vol.30, No.4, pp. 123-129, 2019, DOI:10.1684/ecn.2019.0435

Abstract Introduction: Common Variable Immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiencies. Current research data show altered B cells, TLRs, and cytokine profile in CVID patients. The aim of this study was to determine levels of IL-1β and IL-6 in CVID patients in response to TLRs stimulation and the association of these cytokines with subtypes of B cells and response to Pneumovax-23 vaccination. Method: Peripheral blood mononuclear cells of CIVD patients were stimulated with and without TLR2 and TLR4 agonist and specific inhibitors including lipopolysaccharide (LPS), lipoteichoic (LTA), and OxPAPC. The levels of… More >

Margaret M. Samyn^1,2, Ke Yan¹, Conor Masterson³, Benjamin H. Goot^1,2, David Saudek^1,2, Julie Lavoie², Aaron Kinney², Mary Krolikowski¹, Kan Hor^4,5, Scott Cohen^1,2

Congenital Heart Disease, Vol.14, No.6, pp. 1138-1148, 2019, DOI:10.1111/chd.12861

Abstract Objective: Patients with Dextro-transposition of the great arteries status post atrial switch (dTGA s/p atrial switch) are “at-risk” for systemic right ventricular (RV) dysfunction. Due to complex RV geometry, echocardiography (Echo) does not allow accurate determination of ejection fraction (EF), but cardiac magnetic resonance imaging (CMR) allows quantitative right ventricular assessment. Measures of ventricular deformation may be precursors to global ventricular dysfunction. The primary aim of this study was to characterize imaging and clinical findings for adult patients with dTGA s/p atrial switch.
Design: This was a retrospective cohort study of patients with dTGA s/p atrial switch… More >