Novik Budiwardhana1,*, Indah Kartika Murni2, Eva Miranda Marwali1, Pribadi Wiranda Busro3, Fildza Intan Rizkia4, Muhamad Faza Soelaeman4, Yunita Widyastuti5
Congenital Heart Disease, Vol.20, No.5, pp. 591-600, 2025, DOI:10.32604/chd.2025.070345
- 30 November 2025
Abstract Background: Low cardiac output syndrome (LCOS) is a frequent and serious complication after pediatric cardiac surgery. Endothelial glycocalyx (EG) degradation, indicated by elevated syndecan-1, contributes to microvascular dysfunction and postoperative instability. The relationship between syndecan-1 dynamics and surgical risk categories remains unclear. Objective: To examine the association between perioperative syndecan-1 levels and clinical outcomes across Risk Adjustment for Congenital Heart Surgery (RACHS-1) categories. Methods: We analyzed 106 children (RACHS-1 categories 2–4) undergoing elective cardiac surgery with cardiopulmonary bypass (CPB). Syndecan-1 was measured at baseline (T0), 4 h (T4), and 72 h (T72). Outcomes included LCOS, vasoactive inotropic… More >
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