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  • Open Access


    Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo

    Antonello Di Paolo1, Paola Orlandi1, Teresa Di Desidero, Romano Danesi, Guido Bocci

    Oncology Research, Vol.25, No.7, pp. 1129-1140, 2017, DOI:10.3727/096504017X14841698396900

    Abstract The combination of folinate salts to 5-fluoruracil (5-FU)-based schedules is an established clinical routine in the landscape of colorectal cancer treatment. The aim of this study was to investigate the pharmacological differences between the sequential administration of folinate salts (1 h before, as in clinical routine) followed by 5-FU and the simultaneous administration of both drugs. Proliferation and apoptotic assays were performed on human colon cancer cells exposed to 5-FU, calcium (CaLV), or disodium (NaLV) levofolinate or their simultaneous and sequential combination for 24 and 72 h. TYMS and SLC19A1 gene expression was performed with… More >

  • Open Access


    A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

    Verônica Távilla Ferreira Silva, Adriane Maria Ferreira Milagres*

    Journal of Renewable Materials, Vol.12, No.3, pp. 539-551, 2024, DOI:10.32604/jrm.2023.045726

    Abstract This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving pulp. Our goal was to determine the contributions of xylanase (X) and endoglucanase (EG) in the treatment of pulp, specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid (DNS) test. Predominantly, the release of soluble reducing sugars (RSSol) was enhanced after xylanase treatment, while endoglucanase (EG) treatment led to changes in insoluble reducing sugars (RSIns). The maximum synergism was observed for RSIns when a… More > Graphic Abstract

    A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

  • Open Access


    Cancer combination therapy with carnosic acid


    BIOCELL, Vol.46, No.10, pp. 2151-2157, 2022, DOI:10.32604/biocell.2022.019937

    Abstract Carnosic acid (CA) is a natural phenolic diterpene mainly occurring in some species of the Lamiaceae family. Numerous studies described the cytotoxicity of CA towards different types of cancer both in vitro and in vivo. Particularly, the influence of CA in combination with other drugs, vitamins or natural products through affecting various targets has raised interest. Current experimental in vivo data suggested that CA may cooperate with clinically used anticancer drugs promoting their activity against cancer. From this point of view, CA gained importance, because it may alter pharmacodynamic profiles of various agents in the More >

  • Open Access


    Effect of Mitigating Strength Retrogradation of Alkali Accelerator by the Synergism of Sodium Sulfate and Waste Glass Powder

    Yongdong Xu, Tingshu He*

    Journal of Renewable Materials, Vol.9, No.11, pp. 1991-1999, 2021, DOI:10.32604/jrm.2021.015931

    Abstract This work aims to utilize waste glass powder (WGP) as a plementary material to mitigate the strength shrinkage caused by the alkaline accelerator. Waste glass power was used to replace cement by 0%, 10%, and 20% to evaluate waste glass powder on the alkaline accelerator’s strength retrogradation. The results show that the strength improvement effect of unitary glass powder is inconspicuous. Innovative methods have been proposed to use sodium sulfate and waste glass powder synergism, using the activity of amorphous silica in glass powder. Compared with the reference group, the compressive strength of 28d mortar More >

  • Open Access


    Synergism of flavonoids with bacteriostatic action against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922


    BIOCELL, Vol.30, No.1, pp. 39-42, 2006, DOI:10.32604/biocell.2006.30.039

    Abstract In our previous studies, bacteriostatic action of flavonoids against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922 was demostrated. In the present work synergism of their combinations in order to improve the bacteriostatic action against the same microorganisms was determined. The experiences were made in nutritive broth, maintaining constant one drug concentration (20 µg/ml) and increasing the other one. A turbidimetric kinetic method was used and by means of a mechanism previously proposed, the minimal inhibitory concentrations (MIC´s) of each flavonoid combination were determined. The MIC´s for assayed combinations against S. aureus were: variable morin More >

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