YANG YANG1,*, BENSHUAI YOU2, CHENGLIN ZHOU1,*
BIOCELL, Vol.46, No.6, pp. 1557-1564, 2022, DOI:10.32604/biocell.2022.018326
Abstract The gene of Helicobacter pylori can encode three to four type IV secretory systems, of which a new gene region has been found in the H. pylori plasticity region. The coding products of this region can form a new T4SS named tfs3, but its function is unclear. This study investigated the effect of VirD4 recombinant protein in the tfs3 secretory system of the H. pylori clinical strain SBK on GES-1 cells. We observed changes in cell morphology after VirD4 treatment. Further analysis indicated that VirD4 increased inflammation by increasing the activation of NF-κB. VirD4 can also inhibited proliferation, and induced… More >
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