Yanan Wang∗, Qing-Hua Qin∗, Shankar Kalyanasundaram∗
Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 101-112, 2009, DOI:10.3970/mcb.2009.006.101
Abstract A mathematical model is developed for simulating anabolic behaviour of bone affected by Parathyroid Hormone (PTH) in this paper. The model incorporates a new understanding on the interaction of PTH and other factors with the RANK-RANKL-OPG pathway into bone remodelling, which is able to simulate anabolic actions of bone induced by PTH at cellular level. The RANK-RANKL-OPG pathway together with the dual action of TGF-$\beta$, which represent the core of coupling behaviour between osteoblasts and osteoclasts which are two cell types specialising in the maintenance of bone integrity, are widely considered essential for the regulation of bone remodelling at cellular… More >
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