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  • Open Access

    ARTICLE

    Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity

    Anne Riemann*, Antje Güttler, Verena Haupt*, Henri Wichmann, Sarah Reime*, Matthias Bache, Dirk Vordermark, Oliver Thews*

    Oncology Research, Vol.26, No.2, pp. 191-200, 2018, DOI:10.3727/096504017X14965111926391

    Abstract Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells with regard to potential therapeutic implications. CA IX was upregulated by hypoxia as well as acidosis in prostate cancer cells. This induction… More >

  • Open Access

    ARTICLE

    A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

    SHAHID KARIM1,*, ALANOUD NAHER ALGHANMI1, MAHA JAMAL1, HUDA ALKREATHY1, ALAM JAMAL2, HIND A. ALKHATABI3, MOHAMMED BAZUHAIR1, AFTAB AHMAD4,5

    Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988

    Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as More > Graphic Abstract

    A comparative <i>in vitro</i> study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

  • Open Access

    ARTICLE

    Green Synthesis of Reduced Graphene Oxide Nanosheet by using L-ascorbic Acid and Study of its Cytotoxicity on Human Cervical Cancer Cell Line

    PRABHAT KUMAR, ANJANA SARKAR, PURNIMA JAIN*

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 121-135, 2022, DOI:10.32381/JPM.2022.39.1-2.8

    Abstract Biocompatible graphene derivative materials (GBMs) to harness the maximum potential of pristine graphene biologically, is the most important strategy for its advanced applications in pharmaceutical and other biomedical fields. Currently, scientists are trying to find this by using biopolymer nanocomposites or anchored materials. Nevertheless, tuning the bare GBMs towards biocompatibility is a beautiful approach to exploit the fundamental potential of pristine graphene vis-à-vis suppressing the effects of incorporated biopolymers or anchored materials. Herein, a large-scale, cost-effective, facile, and environment-friendly green synthetic strategy is used for the synthesis of reduced graphene oxide (rGO) nanosheet using L-ascorbic… More >

  • Open Access

    ARTICLE

    Silicon Mitigates Aluminum Toxicity of Tartary Buckwheat by Regulating Antioxidant Systems

    Anyin Qi1,#, Xiaonan Yan1,#, Yuqing Liu1,#, Qingchen Zeng1, Hang Yuan1, Huange Huang1, Chenggang Liang2, Dabing Xiang1, Liang Zou1, Lianxin Peng1, Gang Zhao1, Jingwei Huang1,*, Yan Wan1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 1-13, 2024, DOI:10.32604/phyton.2023.045802

    Abstract

    Aluminum (Al) toxicity is a considerable factor limiting crop yield and biomass in acidic soil. Tartary buckwheat growing in acidic soil may suffer from Al poisoning. Here, we investigated the influence of Al stress on the growth of tartary buckwheat seedling roots, and the alleviation of Al stress by silicon (Si), as has been demonstrated in many crops. Under Al stress, root growth (total root length, primary root length, root tips, root surface area, and root volume) was significantly inhibited, and Al and malondialdehyde (MDA) accumulated in the root tips. At the same time, catalase (CAT)

    More >

  • Open Access

    ARTICLE

    Comprehensive Assessment of the Safety of Eucommia ulmoides Leaf Extract for Consumption as a Traditional Chinese Health Food

    Huiling Fu1, Mijun Peng2, Qiuwen Tang2, Haojun Liang2, Yanli Liang2, Jiali Fang2,*, Xuesong Wang2,*

    Journal of Renewable Materials, Vol.11, No.7, pp. 3091-3114, 2023, DOI:10.32604/jrm.2023.026689

    Abstract To ensure the export quality of Eucommia ulmoides leaf extract (ELE) and facilitate E. ulmoides leaf inclusion in the directory of traditional Chinese health foods, an overall safety assessment of ELE was performed, including genotoxicity and long-term toxicity, according to the national food safety standards of China. No variations in the reverse mutation number of the nominal bacterial strains were observed under ELE treatment in comparison with the solvent control. Additionally, the micronucleus rates of in vivo mammalian erythrocytes and in vitro mammalian cells under ELE treatment were equivalent to or significantly lower than those of the… More > Graphic Abstract

    Comprehensive Assessment of the Safety of <i>Eucommia ulmoides</i> Leaf Extract for Consumption as a Traditional Chinese Health Food

  • Open Access

    ARTICLE

    Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study

    OZAN CEM GULER1,*, EZGI OYMAK2, GOZDE YAZICI3, OZLEM OZKAYA AKAGUNDUZ4, OGUZ CETINAYAK5, PETEK ERPOLAT6, ATIL AKSOY7, MURSEL DUZOVA8, BERNA AKKUS YILDIRIM9, MERAL KURT10, EMINE CANYILMAZ11, GULER YAVAS12, SERAP AKYUREK13, DIDEM COLPAN OKSUZ14, ESRA KAYTAN SAGLAM15, OMUR KARAKOYUN CELIK16, ENIS OZYAR17, MUSTAFA CENGIZ3, CEM ONAL1,2,12

    Oncology Research, Vol.31, No.3, pp. 299-306, 2023, DOI:10.32604/or.2023.028840

    Abstract The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma (CEC) patients who underwent definitive chemoradiotherapy (CRT). The clinical data of 175 biopsy-confirmed CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively analyzed. The prognostic factors predicting overall survival (OS), progression-free survival (PFS), and local recurrence-free survival (LRFS) were assessed in uni- and multivariable analyses. The median age of the entire cohort was 56 years (range: 26–87 years). All patients received definitive radiotherapy with a median total dose of 60 Gy, and… More >

  • Open Access

    ARTICLE

    Konjac glucomannan enhances 5-FU-induced cytotoxicity of hepatocellular carcinoma cells via TLR4/PERK/CHOP signaling to induce endoplasmic reticulum stress

    YONGKANG SHI, JUN MA, KE CHEN, BIN CHEN*

    Oncology Research, Vol.30, No.4, pp. 201-210, 2022, DOI:10.32604/or.2022.027584

    Abstract 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for various cancers. However, the drug resistance developed by tumor cells hinders the therapeutic effect. Konjac glucomannan (KGM) is indicated to sensitize 5-FU-resistant hepatocellular carcinoma (HCC) cells to 5-FU. In our study, we found that KGM or 5-FU treatment alone did not affect the malignant cell behaviors and endoplasmic reticulum (ER) stress of 5-FU-resistant HCC cells or HepG2/5-FU and Bel-7402/5-FU cells, while cotreatment with KGM and 5-FU significantly facilitated HCC cell apoptosis and ER stress and suppressed cell proliferation potential and migration abilities. Moreover, we explored the… More >

  • Open Access

    ARTICLE

    In vitro study of emodin-induced nephrotoxicity in human renal glomerular endothelial cells on a microfluidic chip

    ZHUO YANG#, WEN QIN#, DI CHEN, JUNSHENG HUO, JINGBO WANG, LIYUAN WANG, QIN ZHUO, JIYONG YIN*

    BIOCELL, Vol.47, No.1, pp. 125-131, 2023, DOI:10.32604/biocell.2023.022937

    Abstract Emodin is an effective component of rhubarb with positive pharmacological effects on human health. However, it is also toxic to different cells or tissues to varying degrees. The effects of emodin on glomerular endothelial cells (GECs) remain to be tested, and the documented works were always performed in vitro and hardly reflect the real physiological situation. To study the effects of emodin on GECs in a biomimetic environment, we utilized a microfluidic chip to assess the physiological reaction of human renal glomerular endothelial cells to various concentrations of emodin in this work. The results showed that More >

  • Open Access

    REVIEW

    Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

    MONALISA MISHRA1,2,*, PUNYATOYA PANDA1, BEDANTA KUMAR BARIK1, AMRITA MONDAL1, MRUTUNJAYA PANDA1

    BIOCELL, Vol.47, No.1, pp. 51-69, 2023, DOI:10.32604/biocell.2022.023392

    Abstract Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a More >

  • Open Access

    REVIEW

    Aluminum Toxicity: A Case Study on Tobacco (Nicotiana tabacum L.)

    Munir Ozturk1,*, Mert Metin2, Volkan Altay3, Tomonori Kawano2, Alvina Gul4, Bengu Turkyilmaz Unal5,*, Dilek Unal6, Rouf Ahmad Bhat7, Moonisa Aslam Dervash8, Kristina Toderich9, Esra Koc10, Pedro Garcia Caparros11, Andleeb Shahzadi12

    Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 165-192, 2023, DOI:10.32604/phyton.2022.022038

    Abstract Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic environments. Many plants are affected by the presence of aluminum at the whole plant level, at the organ level, and at the cellular level. Tobacco as a cash crop (Nicotiana tabacum L.) is a widely cultivated plant worldwide and is also a good model organism for research. Although there are many articles on Al-phytotoxicity in the literature, reviews on a single species that are economically and scientifically important are limited. In this article, we not only provide the biology… More >

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