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  • Open Access

    ARTICLE

    Overexpression of RUNX1 mitigates dexamethasone-induced impairment of osteogenic differentiation and oxidative stress injury in bone marrow mesenchymal stem cells by promoting alpha-2 macroglobulin transcription

    QINGJIAN HE1, HUIXIN ZHU2,3, SHANHONG FANG4,5,*

    BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

    Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

  • Open Access

    ARTICLE

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

    HUI SUN, MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

    Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

    Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

  • Open Access

    REVIEW

    The IDD Transcription Factors: Their Functions in Plant Development and Environmental Response

    Jing Liu1,*, Defeng Shu1, Zilong Tan1, Mei Ma1, Huanhuan Yang1, Ning Guo1,2, Shipeng Li1, Dayong Cui1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 63-79, 2024, DOI:10.32604/phyton.2023.045940

    Abstract INDETERMINATE-DOMAIN proteins (IDDs) are a plant-specific transcription factor family characterized by a conserved ID domain with four zinc finger motifs. Previous studies have demonstrated that IDDs coordinate a diversity of physiological processes and functions in plant growth and development, including floral transition, plant architecture, seed and root development, and hormone signaling. In this review, we especially summarized the latest knowledge on the functions and working models of IDD members in Arabidopsis, rice, and maize, particularly focusing on their role in the regulatory network of biotic and abiotic environmental responses, such as gravity, temperature, water, and pathogens. Understanding these mechanisms underlying… More >

  • Open Access

    ARTICLE

    Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

    ROGHAYEH GHORBANI1, MAHMOUD GHARBAVI2, ALI SHARAFI3,4, ELHAM RISMANI5, HAMED REZAEEJAM6, YOUSEF MORTAZAVI1,*, BEHROOZ JOHARI3,*

    Oncology Research, Vol.32, No.1, pp. 101-125, 2024, DOI:10.32604/or.2023.044741

    Abstract In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays. ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure. The physicochemical characteristics of nanostructures were determined by FTIR, DLS, UV-vis, TEM, EDX, in vitro release, and hemolysis tests. Subsequently, the cytotoxicity properties of them with and without X-irradiation were investigated by uptake, MTT, cell cycle, apoptosis, and scratch assays on… More > Graphic Abstract

    Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

  • Open Access

    REVIEW

    Regulatory role of NFAT1 signaling in articular chondrocyte activities and osteoarthritis pathogenesis

    MINGCAI ZHANG, TANNER CAMPBELL, SPENCER FALCON, JINXI WANG*

    BIOCELL, Vol.47, No.10, pp. 2125-2132, 2023, DOI:10.32604/biocell.2023.030161

    Abstract Osteoarthritis (OA), the most common form of joint disease, is characterized clinically by joint pain, stiffness, and deformity. OA is now considered a whole joint disease; however, the breakdown of the articular cartilage remains the major hallmark of the disease. Current treatments targeting OA symptoms have a limited impact on impeding or reversing the OA progression. Understanding the molecular and cellular mechanisms underlying OA development is a critical barrier to progress in OA therapy. Recent studies by the current authors’ group and others have revealed that the nuclear factor of activated T cell 1 (NFAT1), a member of the NFAT… More > Graphic Abstract

    Regulatory role of NFAT1 signaling in articular chondrocyte activities and osteoarthritis pathogenesis

  • Open Access

    Identification of STAT5B as a biomarker for an early diagnosis of endometrial carcinoma

    XUELIAN CHEN1,*, YUNZHENG ZHANG2, JUNJIAN HE3, YIBING LI4

    BIOCELL, Vol.47, No.10, pp. 2283-2300, 2023, DOI:10.32604/biocell.2023.030086

    Abstract Background: The late detection of endometrial carcinoma (EC) at an advanced stage often results in a poor patient prognosis. It is hence important to identify reliable biomarkers to facilitate early detection of EC. Signal transducer and activator of transcription (STAT) family members play an important role in several tumors, however, their impact on EC development and progression remains unclear. Methods: Machine learning methods were used to investigate the importance of STAT5B in EC. Results: Hence, we explored the UALCAN data mining platform and found that while STAT1 and STAT2 were upregulated, STAT5A, STAT5B, and STAT6 were downregulated in EC. This… More >

  • Open Access

    ARTICLE

    The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription

    NING AN1,#, HEQING PENG2,#, MIN HOU3, DUOFENG SU2, LIU WANG4, XIAOGANG SHEN5,*, MING ZHANG1,*

    Oncology Research, Vol.31, No.3, pp. 307-316, 2023, DOI:10.32604/or.2023.028564

    Abstract Zinc-finger proteins play different roles in cancer; however, the function of zinc-finger protein ZNF575 in cancer remains unclear. In the present study, we aimed to determine the function and expression of ZNF575 in colorectal cancer. Proliferation assay, colony formation assay, and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer (CRC) cells. RNA sequencing, ChIP, and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth. The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues, followed by… More > Graphic Abstract

    The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription

  • Open Access

    ARTICLE

    HD-Zip Transcription Factor is Responsible for No-Lobed Leaf in Watermelon (Citrullus lanatus L.)

    Shixiang Duan1,#, Yaomiao Guo1,#, Yinping Wang1, Muhammad Jawad Umer2, Dongming Liu1, Sen Yang1, Huanhuan Niu1, Shouru Sun1, Luming Yang1, Junling Dou1,*, Huayu Zhu1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1311-1328, 2023, DOI:10.32604/phyton.2023.026928

    Abstract Leaf is a vital organ of plants that plays an essential role in photosynthesis and respiration. As an important agronomic trait in leaf development, leaf shape is classified into lobed, entire (no-lobed), and serrated in most crops. In this study, two-lobed leaf watermelon inbred lines WT2 and WCZ, and a no-lobed leaf watermelon inbred line WT20 were used to create two F2 populations. Segregation analysis suggested that lobed leaves were dominant over the no-lobed leaves, and it was controlled by a signal gene. A locus on watermelon chromosome 4 controlling watermelon lobed/no-lobed leaves was identified through BSA-seq strategy combined with… More >

  • Open Access

    ARTICLE

    Genome-Wide Identification and Characterisation of Abiotic Stress Responsive mTERF Gene Family in Amaranthus hypochondriacus

    Mortaza Hajyzadeh*

    Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1649-1664, 2023, DOI:10.32604/phyton.2023.028028

    Abstract Abiotic stresses at different growth stages in the life of plants negatively affect yield productivity. Therefore, plants, including Amaranthus hypochondriacus, develop adaptive strategies to face the stresses and expand functional diversification. In plants, the mitochondrial transcription termination factors (mTERF) are essential functions in regulation, and organelles (mitochondria and chloroplasts) control gene expression (OGE) under several stress conditions. Based on the in-silico-wide genome and transcriptome analysis, twenty-four mTERF genes were detected in the main targeted mitochondria organelles clustered into three different main groups. The chromosomal location and gene duplication analysis indicated one segmental and one tandem duplication in the genome. The… More >

  • Open Access

    ARTICLE

    Characteristics and expression of the TCP transcription factors family in Allium senescens reveal its potential roles in drought stress responses

    XIAOHONG FU1,#, JIE ZHAO3,#, DANDAN CAO1,2, CHENGXING HE1,2, ZIYI WANG1, YIBEI JIANG1, JIANFENG LIU1,*, GUIXIA LIU1,*

    BIOCELL, Vol.47, No.4, pp. 905-917, 2023, DOI:10.32604/biocell.2023.026930

    Abstract Allium senescens, is an important economic and ecological grassland plant with drought-resistant characteristics. A TCP protein transcription factor is important in the regulation of plant development and adverse responses. However, the mechanism by which TCP transcription functions in drought resistance in Allium senescens is still not clear. Here, we obtained a total of 190,305 transcripts with 115,562 single gene clusters based on RNA-Seq sequencing of Allium senescens under drought stress. The total number of bases was 97,195,096 bp, and the average length was 841.06 bp. Furthermore, we found that there were eight genes of the TCP family that showed an… More >

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