Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a corepressor for the transcription factor PBX. Previous studies showed that HPIP is frequently overexpressed in
many tumors. However, the role of HPIP in head-and-neck squamous cell carcinoma (HNSCC) has not yet
been determined. Thus, we decided to investigate the effects and mechanisms of HPIP in HNSCC. Our results
demonstrated that HPIP is highly expressed in human HNSCC cell lines and provides the first evidence that
knockdown of HPIP obviously inhibits proliferation and migration/invasion in HNSCC cells in vitro, as well as
inhibits tumor growth in vivo. Furthermore, knockdown of HPIP significantly inhibits the expression of p-PI3K
and p-Akt in human HNSCC cells. In conclusion, our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K/Akt signaling
pathway. Therefore, HPIP may be a novel potential therapeutic target for the treatment of HNSCC.
Cite This Article
APA Style
Chen, Y., Zhao, R., Zhao, Q., Shao, Y., Zhang, S. (2016). Knockdown of HPIP inhibits the proliferation and invasion of head-and-neck squamous cell carcinoma cells by regulating pi3k/akt signaling pathway. Oncology Research, 24(3), 153-160. https://doi.org/10.3727/096504016X14612603423476
Vancouver Style
Chen Y, Zhao R, Zhao Q, Shao Y, Zhang S. Knockdown of HPIP inhibits the proliferation and invasion of head-and-neck squamous cell carcinoma cells by regulating pi3k/akt signaling pathway. Oncol Res. 2016;24(3):153-160 https://doi.org/10.3727/096504016X14612603423476
IEEE Style
Y. Chen, R. Zhao, Q. Zhao, Y. Shao, and S. Zhang "Knockdown of HPIP Inhibits the Proliferation and Invasion of Head-and-Neck Squamous Cell Carcinoma Cells by Regulating PI3K/Akt Signaling Pathway," Oncol. Res., vol. 24, no. 3, pp. 153-160. 2016. https://doi.org/10.3727/096504016X14612603423476