NURAN BEDOLLA^#, HAO WU^#, LINYU LIU, XUETING LIU, YANLI REN^*

Oncology Research, Vol.33, No.6, pp. 1473-1484, 2025, DOI:10.32604/or.2025.060151 - 29 May 2025

Abstract Background: Gallic acid (GA), a plant-derived polyphenol, possesses diverse biological functions such as reducing inflammation and against tumors. Currently, the influence of GA on the resistance of esophageal squamous cell carcinoma (ESCC) cells to cisplatin (DDP) is not well understood. Methods: Cell counting kit-8 assay examined how GA affected KYSE30 and TE-1 cell viability. 5-Ethynyl-2′-deoxyuridine and TdT-mediated dUTP Nick-End labeling staining detected cell proliferation and apoptosis. Clone formation assay, flow cytometry, Carboxyfluorescein diacetate succinimidyl ester fluorescent probes, and Transwell assay determined cell biological properties, and 2′,7′-Dichlorofluorescin diacetate (DCFH-DA) fluorescent probes detected oxidative stress levels. Signal… More > Graphic Abstract

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

Saif Ullah^1,2, Izhar Ali^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1029-1045, 2025, DOI:10.32604/phyton.2025.064608 - 30 April 2025

Abstract Nitrogen (N) assimilation is crucial for the growth and development of C₃ plants, as it converts inorganic N into organic forms, important for protein synthesis, nucleic acids and other vital biomolecules. However, abiotic stressors such as drought, salinity, extreme temperatures and others significantly impact N uptake and utilization, thereby hindering plant growth and development. Recent advances in molecular biology have illuminated the complex networks that govern N assimilation under these stressful conditions, emphasizing the role of transcription factors, regulatory genes, and stress-responsive pathways. This review provides an integrated perspective on the latest research in nitrogen metabolism… More >

Yuhang Li¹, Li Sun¹, Tao Wang¹, Bingjun Yu², Zhihong Gao³, Xiaochun Shu¹, Tengyue Yan¹, Weibing Zhuang^1,2,*, Zhong Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1211-1223, 2025, DOI:10.32604/phyton.2025.063647 - 30 April 2025

Abstract bHLH transcription factors, widely exist in various plants, and are vital for the growth and development of these plants. Among them, many have been implicated in anthocyanin biosynthesis across various plants. In the present study, a PdbHLH57 gene, belonging to the bHLH IIIf group, was characterized, which was isolated and cloned from the colored-leaf poplar ‘Zhongshancaiyun’ (ZSCY). The cDNA sequence of PdbHLH57 was 1887 base pairs, and the protein encoded by PdbHLH57 had 628 amino acids, the isoelectric point and molecular weight of which were 6.26 and 69.75 kDa, respectively. Through bioinformatics analysis, PdbHLH57 has been classified… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

Abstract This article has no abstract. More >

XIUWANG WEI¹, JIANBO LIANG¹, HUANWEN HUANG¹, DAMING YANG¹, XINXIN WANG¹, XIUJIA WANG¹, CHANGSHENG CHEN¹, KAIQIANG LI¹, TAISEN PANG¹, BIN HU¹, FENGNING WU^2,*

Oncology Research, Vol.33, No.1, pp. 161-169, 2025, DOI:10.32604/or.2024.048054 - 20 December 2024

Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >

Jianbo Fei^1,2,4, Zhibo Liu¹, Piwu Wang^1,3, Jing Qu², Siyan Liu¹, Shuyan Guan^1,3,*, Yiyong Ma^1,3

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3617-3635, 2024, DOI:10.32604/phyton.2024.052704 - 31 December 2024

Abstract The WRKY transcription factors play important roles in various biological processes such as plant development, defense regulation, and stress response. Despite this, there is limited information available on drought-related WRKY genes in maize. Through RNA sequencing (RNA-seq) analysis, a WRKY transcription factor called ZmWRKY25 was identified in this study. ZmWRKY25 belongs to Group II and is localized in the nucleus. Protein interaction analysis revealed that ZmWRKY25 interacts with several proteins involved in the abscisic acid (ABA) signal pathway. Expression of ZmWRKY25 was found to be up-regulated in response to drought, salt, and ABA treatments in tobacco plants. More >

Yue Zhao^1,2,#, Shah Faheem Afzal^2,#, Zhu Chen², Khan Arif Kamal^1,2, Yuzhi Fei², Xin Meng^1,2, Jie Ren^2,*, Hua Liu^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3109-3130, 2024, DOI:10.32604/phyton.2024.056548 - 30 November 2024

Abstract Acer rubrum is an important garden color-leafed plant. Its leaves will turn red in autumn, which is of great ornamental value. The leaf color change in Acer rubrum is closely associated with anthocyanins accumulation. In anthocyanin synthesis and accumulation, various transcription factor families play significant regulatory roles, including the basic (region) leucine zipper (bZIP). However, there is no report on the systematic identification and functional analysis of the bZIPs in Acer rubrum. In this study, 137 bZIPs distributed on 29 chromosomes of Acer rubrum were identified and renamed according to their locations on the chromosomes. According to the constructed… More >

YUAN YIN¹, ZHENGYIN WANG¹, YUJIE HU¹, JIA WANG¹, YI WANG^2,*, QUN LU^1,*

Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

Jun Yuan¹, Rongpeng Liu⁴, Xiaoyun Wang^3,*, Haihui Fu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2267-2284, 2024, DOI:10.32604/phyton.2024.055338 - 30 September 2024

Abstract Cadmium (Cd) has seriously affected the quality of traditional Chinese medicinal material Salvia miltiorrhiza in recent years, threatening human health. The physiological and metabolic profiles of S. miltiorrhiza in response to Cd stress have been revealed in previous studies. However, transcriptional and post-transcriptional regulation in response to different degrees of Cd (0, 25, 50, and 100 mg/kg) stress in S. miltiorrhiza remains unclear. Here, transcriptome atlas in S. miltiorrhiza under different degrees of Cd Stress was unveiled using RNA sequencing (RNA-seq). These results showed that the profiles of gene expression were different in the response to Cd treatment. Defense More >