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  • Open Access


    Anatomic Correlates of Mitral Systolic Anterior Motion in Transposition of the Great Arteries Following Atrial Switch Operation

    Norman Aiad1,2,3,7, Mark V. Sherrid1,7, Adam J. Small1, Youssef Elnabawi1,7, Jodi Feinberg1, Leon Axel1,4, Ralph Mosca5, T. K. Susheel Kumar5, Michael Argilla6, Dan G. Halpern1,7,*

    Congenital Heart Disease, Vol.18, No.3, pp. 267-277, 2023, DOI:10.32604/chd.2023.025853

    Abstract Introduction: We sought to investigate whether the development of sub-pulmonic systolic anterior motion (SAM) may be inherent to the anatomy of the the mitral valve (MV) or affected by external factors, such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation (d-TGA/AtS). Methods: Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS (age 42 ± 6 years old, 56% male) between 2015–2019. Echocardiography data included mitral apparatus anatomy, and CT/MRI data included biventricular dimensions, function, and Haller index (HI) for pectus deformity. Results:More >

  • Open Access


    Transcatheter Device Closure of a Perimembranous Ventricular Septal Defect in Congenitally Corrected Transposition of the Great Arteries

    Catherine E. Tomasulo1,*, Lindsay S. Rogers1, Lauren Andrade1,2, Michael L. O’Byrne1,3,4

    Congenital Heart Disease, Vol.17, No.2, pp. 193-199, 2022, DOI:10.32604/chd.2022.017721

    Abstract The majority of patients with congenitally corrected transposition of the great arteries, also known as transposition of the great arteries {S,L,L} have ventricular septal defects (VSD), most commonly perimembranous VSD (pmVSD). Transcatheter device closure of pmVSD in these patients has not been widely described. We present a case of device closure of pmVSD in L-TGA with an Amplatzer Duct Occluder II (ADOII) device using a deployment starting in the subpulmonary left ventricle. The case demonstrates some of the technical advantages of the ADOII device for VSD closure, specifically its low profile, symmetric shape, and soft material. These characteristics are advantageous… More >

  • Open Access


    A Rare Case of Late LAD Reimplantation after Arterial Switch Operation

    Yannick Kabulo Kolela1,2, Maureen Klepper1,2, Geoffroy de Beco1,2, Thierry Sluysmans3, Alain Poncelet1,2,*

    Congenital Heart Disease, Vol.17, No.1, pp. 99-106, 2022, DOI:10.32604/CHD.2022.017635

    Abstract Arterial switch operation (ASO) is a complex neonatal operation in which transfer of the coronary arteries origins is the key to success. Coronary events after a successful ASO are not uncommon. We describe a rare case of a child who underwent an ASO in the neonatal period with one coronary (LAD) described as atretic left in place. At age seven, he developed myocardial ischemia due to retrograde flow with a steal phenomenon from the LAD into the pulmonary artery. The patient underwent a late LAD reimplantation. This case underscores that even very small ostia should be translocated at the time… More >

  • Open Access


    Six-Year Outcome after Valve Replacement and Resynchronization Therapy in TGA Patient

    Jadranka Separovic Hanzevacki1, Marija Brestovac1,*, Vlatka Reskovic Luksic1, Blanka Glavas Konja1, Martina Lovric Bencic1, Josko Bulum1, Darko Anic2

    Congenital Heart Disease, Vol.16, No.5, pp. 469-475, 2021, DOI:10.32604/CHD.2021.015237

    Abstract Patients with complete transposition of the great arteries (TGA) treated by the Senning procedure have a higher risk of developing heart failure due to: a) additional work load of the systemic (morphologic right) ventricle (sRV), b) arrhythmias, mainly caused by surgical implications at the atria as well as c) worsening of systemic tricuspid regurgitation. We present a unique case of a female patient who developed all these complications, who was successfully treated and was able to carry out a twin pregnancy. This breakthrough approach was based on: 1. detecting reversibility potential of myocardial systolic dysfunction in a severe valvular lesion… More >

  • Open Access


    Isolation of the Left Subclavian Artery in D-Transposition of the Great Arteries with Right Aortic Arch

    Kotaro Hine*, Kohei Ogata, Keiko Saitou, Norio Mizukaki, Hiroko Arai, Hitoshi Yoda

    Congenital Heart Disease, Vol.16, No.4, pp. 369-371, 2021, DOI:10.32604/CHD.2021.014516

    Abstract Abnormal branching of the aorta associated with the right aortic arch (RAA) has been reported as isolation of left subclavian artery (ILSA), isolation of left common carotid artery, isolation of brachiocephalic artery. ILSA is a rare aortic branch anomaly that originates in the left subclavian artery from the pulmonary artery via ductus arteriosus. Several reports have described ILSA associated with 22q11.2 deletion syndrome and tetralogy of Fallot. Here, we present a very unusual case of RAA with ILSA associated with D-transposition of the great arteries and inferior vena cava interrupted with azygos continuation. More >

  • Open Access


    3.0T MR Coronary Angiography after Arterial Switch Operation for Transposition of The Great Arteries—Gd-FLASH Versus Non-Enhanced SSFP. A Feasibility Study

    Kathrine Rydén Suther1,*, Charlotte de Lange1,2, Henrik Brun3, Rolf Svendsmark1, Bac Nguyen1, Stig Larsen4, Bjarne Smevik1, Arnt Eltvedt Fiane5,6, Harald Lauritz Lindberg6, Einar Hopp1

    Congenital Heart Disease, Vol.16, No.2, pp. 107-121, 2021, DOI:10.32604/CHD.2021.014164

    Abstract Background: Patency of the coronary arteries is an issue after reports of sudden cardiac death in patients with transposition of the great arteries (TGA) operated with arterial switch (ASO). Recent studies give rise to concern regarding the use of ionising radiation in congenital heart disease, and assessment of the coronary arteries with coronary MR angiography (CMRA) might be an attractive non-invasive, non-ionising imaging alternative in these patients. Theoretically, the use of 3.0T CMRA should improve the visualisation of the coronary arteries. The objective of this study was to assess feasibility of 3.0T CMRA at the coronary artery origins by comparing… More >

  • Open Access


    Late-Onset Pulmonary Hypertension After the Atrial Switch Procedure for Transposition of the Great Arteries

    Masataka Ogiso1,2, Kei Inai1,*, Morio Shoda2, Nobuhisa Hagiwara2, Hisashi Sugiyama1

    Congenital Heart Disease, Vol.15, No.6, pp. 483-493, 2020, DOI:10.32604/CHD.2020.013058

    Abstract Background: Pulmonary hypertension (PH) is one of the complications that can occur after the atrial switch procedure for transposition of the great arteries (TGA). This study aimed to assess the characteristics and prognosis of late-onset PH after the atrial switch procedure using catheterization data. Methods and Results: We retrospectively identified 40 patients with TGA after the atrial switch procedure that underwent catheterization between April 2007 and March 2020. Eligible patients were divided into two groups based on PH presence (PH group, n = 13 [33%]; non-PH group, n = 27 [67%]). Adverse events were defined as cardiac death and heart… More >

  • Open Access


    Abnormal Coronary Anatomy in Patients with Transposition of the Great Arteries and Atrial Switch: A Predictor of Serious Cardiac Adverse Events?

    Yoann Perreux1, Marie Alexandre Chaix2, Anna Kamp3, François-Pierre Mongeon2, Magali Pham2, Loïc Boussel1, Roland Henaine1, Annie Dore2, Blandine Mondésert2, Sylvie Di-Filippo1, Paul Khairy2, Francis Bessiere1,*

    Congenital Heart Disease, Vol.15, No.6, pp. 473-482, 2020, DOI:10.32604/CHD.2020.013032

    Abstract Sudden cardiac death and heart failure are well known long-term complications after atrial switch for D-transposition of the great arteries (D-TGA). Right systemic ventricular dysfunction is common and myocardial ischemia has been implicated as a putative mechanism for sudden death, with coronary anomalies prevalent in 30% of cases. We sought to assess an association between adverse events and coronary anomalies in patients with D-TGA and atrial switch surgery. An observational study was conducted in 3 tertiary centers (Montreal Heart Institute, Canada, Nationwide Children’s hospital, Chicago, USA and Hopital cardiologique Louis Pradel de Lyon, France). Adults with D-TGA and atrial switch… More >

  • Open Access


    FFR-Guided PCI in a 17-Year-Old Patient after Arterial Switch Operation for D-Transposition of the Great Arteries

    Domenico Sirico1, Biagio Castaldi1,*, Giuseppe Tarantini2, Giovanni Di Salvo1

    Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863

    Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically induced hyperemia. Thus, the patient… More >

  • Open Access


    Comprehensive Long-Term Follow up of Adults with Arterial Switch Operation– European Collaboration for Prospective Outcome Research in Congenital Heart Disease (EPOCH-ASO)–Study Design and Protocols

    Francisco Javier Ruperti-Repilado1,#,*, Magalie Ladouceur2,#, Pastora Gallego3, Laura Dos4, Joaquin Rueda Soriano5, Berto Bouma6, Harald Gabriel7, Markus Schwerzmann1, Judith Bouchardy8,9, Daniel Tobler10,#, Matthias Greutmann11,#

    Congenital Heart Disease, Vol.15, No.5, pp. 309-338, 2020, DOI:10.32604/CHD.2020.012599

    Abstract Background: Long-term outcomes in adults with prior arterial switch operation (ASO) have not yet been well defined. The aim of this study is to elucidate incidence and predictors of adverse cardiac outcomes in a prospectively followed cohort of adults after their ASO. Methods: The comprehensive longterm follow up of adults with ASO is a project within the European collaboration for prospective outcome research in congenital heart disease (EPOCH). It is designed as a prospective, international multicenter cohort study. Consecutive patients (age ≥ 16 years) with prior ASO will be included at 11 European tertiary care centers. Participants will be followed… More >

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