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  • Open Access


    Effect of Cardioplegia for Myocardial Protection in Pediatric Cardiac Surgery: A Network Meta-Analysis

    Ke Zhou1, Dongyu Li1, Xintong Zhang2, Wensheng Wang1, Shusen Li1, Guang Song2,*

    Congenital Heart Disease, Vol.16, No.6, pp. 609-645, 2021, DOI:10.32604/CHD.2021.016396

    Abstract Cardioplegia has been widely used to reduce myocardial injury during pediatric cardiac surgery; however, which cardioplegia solution has the best protective effect has not been established. Thus, we compared the myocardial protective effects of different cardioplegia solutions used in pediatric cardiac surgery. Seven databases were searched to identify the relevant randomized controlled trials. A network meta-analysis with a Bayesian framework was conducted. The outcomes included the following biochemical and clinical outcomes: serum concentrations of the creatine kinase-myocardial band at 6 h postoperatively; cardiac troponin I (cTnI) at 4, 12, and 24 h postoperatively; spontaneous beating… More >

  • Open Access


    Cardiac Troponin Levels after Percutaneous Atrial Septal Defect Closure: A Qualitative Systematic Review and Meta-Analysis

    Alejandro E. Contreras1,*, Alejandro R. Peirone2, Eduardo Cuestas3

    Congenital Heart Disease, Vol.15, No.1, pp. 13-20, 2020, DOI:10.32604/CHD.2020.011575

    Abstract Introduction: We conducted a systematic review and meta-analysis of published studies to determine the prevalence of troponin elevation after percutaneous atrial septal defect closure (pASDc) as well as to describe the association between troponin elevation and different anatomical risk factors for erosion. Methods: A qualitative systematic review and meta-analysis was undertaken. The selected studies included patients of any age receiving a pASDc; performed under transesophageal echocardiography monitoring; reporting troponin level measurement after the intervention; and indicating prevalence of troponin elevation and/or the association with risk factors for erosion. Results: Six studies were found which included 391 patients… More >

  • Open Access


    Risk factor analysis for a complicated postoperative course after neonatal arterial switch operation: The role of troponin T

    Martin Christmann1,2, Alexandra Wipf1,2, Hitendu Dave2,3, Daniel Quandt1,2, Oliver Niesse1,2, Markus Deisenberg2,4, Martin Hersberger2,5, Oliver Kretschmar1,2, Walter Knirsch1,2

    Congenital Heart Disease, Vol.13, No.4, pp. 594-601, 2018, DOI:10.1111/chd.12615

    Abstract Objective: To find risk factors for a complicated early postoperative course after arterial switch operation (ASO) in neonates with d-transposition of the great arteries (dTGA). In addition to anatomical and surgical parameters, the predictive value of early postoperative troponin T (TnT) values in correlation to the early postoperative course after ASO is analyzed.
    Methods: Seventy-nine neonates (57 (72%) male) with simple dTGA treated by ASO between 2009 and 2016 were included in the analysis. A complicated early postoperative course (30 days) was defined by one of the following criteria: (A) moderate to severe cardiac dysfunction without rhythm… More >

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