Amalia Lamana1,*, Ana M. Ortiz1,*, José M. Alvaro-Gracia1, Belén Díaz-Sánchez1, Jesús Novalbos2, Rosario García-Vicuña1, Isidoro González-Álvaro1
European Cytokine Network, Vol.21, No.3, pp. 186-194, 2010, DOI:10.1684/ecn.2010.0203
Abstract As interleukin-15 (IL-15) has been implicated in the pathophysiology of rheumatoid arthritis, we
analysed the serum IL-15 (sIL-15) levels in healthy subjects and patients with early arthritis to establish a
cut-off point that might serve to define elevated sIL-15. This is an initial step to determine whether sIL-15 has
the potential for use as a biomarker for patients with early arthritis. The IL-15 concentration was measured in
serum obtained from 161 healthy controls and from 174 patients with early arthritis, and the relationship
between the expression of the two IL-15 mRNA variants and the sIL-15… More >