Milica Karadzic Kocica¹, Hristina Ugrinovic¹, Dejan Lazovic², Nemanja Karamarkovic², Milos Grujic², Borivoje Lukic³, Oliver Radmili³, Vladimir Cvetic³, Mladen Kocica^2,*

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016923

Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare clinical and surgical scenario. More >

Laura Schweikert¹, Dominik Gabbert¹, Sylvia Krupickova², Inga Voges^1,*

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016635

Abstract Background: An isolated bicuspid aortic valve (BAV) is associated with structural and functional abnormalities of the aorta and the left ventricle (LV). Although ~50% of patients with aortic coarctation (CoA) have a BAV, less is known about its impact on LV function and aortic geometry and function in CoA patients. In this cardiovascular magnetic resonance imaging (CMR) study, we analysed markers of LV and aortic function as well as aortic geometry in a large cohort of CoA patients with a BAV and compared them with CoA patients with a tricuspid aortic valve (TAV). Methods: We included 48 patients with a… More >

Fabrizio Drago^*, Irma Battipaglia, Pietro Paolo Tamborrino, Luigina Porco, Camilla Calvieri, Mario Salvatore Russo, Vincenzo Pazzano, Romolo Remoli, Massimo Stefano Silvetti

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016623

Abstract Background: Cryoablation of accessory pathways (APs) is effective and very safe in children, as previously reported by our group. The aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children, comparing results obtained with the Ensite Velocity^TM and the more recent Ensite Precision^TM 3D mapping systems. Methods and Results: From January 2016 to December 2019, 102 pediatric patients [mean age 12.5 ± 2.8, 62 males (61% of total cohort)] with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our Institution. Fifteen (14.7%) patients had previously undergone catheter ablation. Acute… More >

Ke Zhou¹, Dongyu Li¹, Xintong Zhang², Wensheng Wang¹, Shusen Li¹, Guang Song^2,*

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016396

Abstract Cardioplegia has been widely used to reduce myocardial injury during pediatric cardiac surgery; however, which cardioplegia solution has the best protective effect has not been established. Thus, we compared the myocardial protective effects of different cardioplegia solutions used in pediatric cardiac surgery. Seven databases were searched to identify the relevant randomized controlled trials. A network meta-analysis with a Bayesian framework was conducted. The outcomes included the following biochemical and clinical outcomes: serum concentrations of the creatine kinase-myocardial band at 6 h postoperatively; cardiac troponin I (cTnI) at 4, 12, and 24 h postoperatively; spontaneous beating after declamping; postoperative arrhythmias; inotropic… More >

Sibao Wang, Silin Pan^*, Gang Luo, Zhixian Ji, Na Liu

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016332

Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the Cochrane Library databases from their inception to December 2020. Two reviewers independently screened the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed and random effects models. We used the I-square (I² ) test to examine heterogeneity and the funnel plot Egger’s test was used… More >

Mohammadrafie Khorgami¹, Ali Sadeghpour Tabaei^2,*, Elio Caruso^3,*, Silvia Farruggio³, Negar Omidi⁴, Maryam Moradian¹, Behzad Mohammadpour Ahranjani⁵, Zahra Khajali6 and Rahele Zamani¹

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016271

Abstract Background: Most children in need of cardiac pacemakers remain dependent on the function of the permanent from childhood to adulthood. We sought to evaluate and compare the function between epicardial and endocardial pacemakers in pediatric groups with different conditions. Methods: Between 2012 and 2018, this single-canter study evaluated 44 pediatric patients with indications for epicardial or endocardial pacemakers. Results: The 2 groups, at a median age of 5 (0.1–16) years, were compared concerning the characteristics of the leads used (n = 80: bipolar, unipolar, steroid-eluting, and non–steroid-eluting), survival data, and complications. The reason for pacemaker implantation was congenital complete heart… More >

Kelly Ferri^1,*, Maite Doñate^2,3, Mireia Parra^2,3, Guillermo R. Oviedo¹, Myriam Guerra-Balic¹, Laia Rojano-Doñate⁴, Nicole Blackburn⁵, Ricard Serra-Grima^2,3

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016189

Abstract Background: Aerobic capacity (AC) in adults with congenital heart disease (CHD) is often reduced, mainly due to low confidence levels towards physical activity (PA). The main objective of this study was to estimate the association between PA level and AC (measured as peak of oxygen consumption, VO_2peak) in adults with CHD. Methods: A total of 183 individuals (83 women and 100 men; mean (SD) age 36.9 (11.0) years old) from Vall d’Hebron Hospital, Barcelona-Spain in 2019, participated in this cross-sectional study. The AC was assessed by cardiopulmonary exercise testing (CPET) using a treadmill ramp protocol. Considering values of metabolic equivalent… More >

Lukas Minder¹, Markus Schwerzmann^1,2, Thomas Radtke^1,3, Hugo Saner¹, Prisca Eser¹, Matthias Wilhelm¹, Jean-Paul Schmid^1,4,*

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.016031

Abstract Objective: To extend our knowledge on tolerance of acute high-altitude exposure and hemodynamic response to exercise in adolescents with congenital heart disease (AscCHD) without meaningful clinical or functional restriction. Methods: A symptom limited cardiopulmonary exercise stress test and a non-invasive cardiac output measurement during steady state exercise were performed at 540 m and at 3454 m a.s.l. Symptoms of acute mountain sickness were noted. Results: We recruited 21 healthy controls and 16 AscCHD (59% male, mean age 14.7 ± 1.1 years). Three subjects (2 controls, 1 AscCHD) presented light symptoms of acute mountain sickness (dizziness and headache). During the symptom… More >

Marie Laure Yammine^#,*, Camilla Calvieri^#, Marcello Chinali, Salvatore Giannico, Giulia Cafiero, Ugo Giordano

Congenital Heart Disease, Vol.,

Abstract Background: In recent decades, aortic stenting has become a promising alternative to surgery for both native aortic coarctation and re-stenosis in children and adults. However, comparative long-term outcomes have poorly been investigated. Methods: We included 212 patients with previous aortic repair (19 ± 8.7 years) divided into 3 groups: 139 with single-time surgical repair (CoA-S group); 18 with single-time percutaneous stenting (CoA-PS group); and 55 hybrid patients with multiple aortic procedures because of re-coarctation occurrence (CoA-H group). All patients underwent 24-hour ambulatory blood pressure monitoring and trans-thoracic echocardiography. Results: After a median follow-up of 17 years after aortic repair, antihypertensive… More >

Muyu Qi^1,#, Xiaoping Lan^2,#, Jia Li¹, Junwen Ge¹, Li Shen^1,*, Rufang Zhang^1,*

Congenital Heart Disease, Vol., , DOI:10.32604/CHD.2021.015887

Abstract Objective: Pulmonary atresia (PA) is a rare type of complex cyanotic congenital heart defect characterized primarily by an undeveloped pulmonary valve or pulmonary artery. Therefore, defining a disease-causing gene mutation in a pulmonary atresia family is a possible method of genetic counseling, future prenatal diagnosis, and therapeutic approaches for pulmonary atresia. Methods: Blood samples were collected from six PA family members, and genomic DNA was extracted using the QIAamp DNA Blood Mini Kit. Gene detection was performed using a second-generation sequencing gene panel. Results: Genetic testing results indicated that a heterozygous mutation originating from maternal inheritance was detected in the… More >