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  • Open Access

    ARTICLE

    Post-treatment with plant extracts used in Brazilian folk medicine caused a partial reversal of the antiproliferative effect of glyphosate in the Allium cepa test

    VIVIANE DAL-SOUTO FRESCURA1, ANDRIELLE WOUTERS KUHN1, HAYWOOD DAIL LAUGHINGHOUSE IV2, JUÇARA TEREZINHA PARANHOS1, SOLANGE BOSIO TEDESCO1

    BIOCELL, Vol.37, No.2, pp. 23-28, 2013, DOI:10.32604/biocell.2013.37.023

    Abstract Species of the genus Psychotria are used for multiple purposes in Brazilian folk medicine, either as water infusions, baths or poultices. This study was aimed to evaluate the genotoxic and antiproliferative effects of infusions of Psychotria brachypoda and P. birotula on the Allium cepa test. Exposure to distilled water was used as a negative control, while exposure to glyphosate was used as a positive control. The interaction of extracts (as a post-treatment) with the effects of glyphosate was also studied. Results showed that glyphosate and the extracts of both P. brachypoda and P. birotula reduced the mitotic index as compared… More >

  • Open Access

    ARTICLE

    Age related interaction of dopamine and serotonin synthesis in striatal synaptosomes

    MANOOCHEHR MESSRIPOUR1, AZADEH MESRIPOUR2

    BIOCELL, Vol.37, No.2, pp. 17-21, 2013, DOI:10.32604/biocell.2013.37.017

    Abstract Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin, respectively. Since both enzymes are active in striatum, and affected by age, this study was undertaken to investigate interaction between dopamine and serotonin synthesis in brain striatal synaptosomes of aging rat. Male Wistar rats (3 and 30 month old) were killed by decapitation and brain striatal synaptosomes were prepared by discontinuous Ficoll/sucrose gradient technique. Synaptosomes were incubated in the presence of added pargiline (monoamineoxidase inhibitor), dopamine or serotonin synthesized during 25 min was measured by HPLC, employing electrochemical… More >

  • Open Access

    ARTICLE

    Meta-analysis of the cell cycle related C12orf48

    LOKMAN VARISLI

    BIOCELL, Vol.37, No.1, pp. 11-16, 2013, DOI:10.32604/biocell.2013.37.011

    Abstract The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms that regulate the timing and frequency of DNA replication and cell division. The temporal and spatial expression of the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cells during the cycle. Although the genes involved in interphase are well studied, most of the genes which are involved in mitotic events still remain unidentified. Since, the discovery of mitosis related genes is still incomplete, we performed a co-expression and gene ontology analysis for revealing… More >

  • Open Access

    ARTICLE

    High passage numbers induce resistance to apoptosis in C2C12 muscle cells

    LUCIA PRONSATO, ANABELA LA COLLA, ANA CAROLINA RONDA, LORENA MILANESI, RICARDO BOLAND, ANDREA VASCONSUELO*

    BIOCELL, Vol.37, No.1, pp. 1-9, 2013, DOI:10.32604/biocell.2013.37.001

    Abstract Cell lines with high passage numbers exhibit alterations in cell morphology and functions. In the present work, C2C12 skeletal muscle cells with either low (<20) or high (>60) passage numbers (identified as lC2C12 or h-C2C12, respectively) were used to investigate the apoptotic response to H2 O2 as a function of culture age h-C2C12. We found that older cultures (h-C2C12 group) were depleted of mitochondrial DNA (mtDNA). When we analyzed the behavior of Bad, Bax, caspase-3 and mitochondrial transmembrane potential, we observed that cells in the h-C2C12 group were resistant to H2 O2 induction of More >

  • Open Access

    ARTICLE

    Vibration Based Fault Diagnosis of a Hydraulic Brake System using Variational Mode Decomposition (VMD)

    R. Jegadeeshwaran1, V. Sugumaran2, K.P. Soman3

    Structural Durability & Health Monitoring, Vol.10, No.1, pp. 81-97, 2014, DOI:10.3970/sdhm.2014.010.081

    Abstract In automobile, brake system is an essential part responsible for control of the vehicle. Vibration signals of a rotating machine contain the dynamic information about its health condition. Many research papers have reported the suitability of vibration signals for fault diagnosis applications. Many of them are based on (Fast Fourier Transform) FFT, which have their own drawback with nonstationary signals. Hence, there is a need for development of new methodologies to infer diagnostic information from such non stationary signals. This paper uses vibration signals acquired from a hydraulic brake system under good and simulated faulty… More >

  • Open Access

    ARTICLE

    Fault Diagnosis of Helical Gear Box using Variational Mode Decomposition and Random Forest Algorithm

    Akhil Muralidharan1,2, V. Sugumaran1, K.P Soman3, M. Amarnath4

    Structural Durability & Health Monitoring, Vol.10, No.1, pp. 55-80, 2014, DOI:10.3970/sdhm.2014.010.055

    Abstract Gears are machine elements that transmit motion by means of successively engaging teeth. In purely scientific terms, gears are used to transmit motion. A faulty gear is a matter of serious concern as it affects the functionality of a machine to a great extent. Thus it is essential to diagnose the faults at an initial stage so as to reduce the losses that might be incurred. This necessitates the need for continuous monitoring of the gears. The vibrations produced by gears from good and simulated faulty conditions can be effectively used to detect the faults… More >

  • Open Access

    ARTICLE

    Electromechanical Impedance Method for the Health Monitoring of Bonded Joints: Numerical Modelling and Experimental Validation

    Vincenzo Gulizzi1,2, Piervincenzo Rizzo2,3, Alberto Milazzo4

    Structural Durability & Health Monitoring, Vol.10, No.1, pp. 19-54, 2014, DOI:10.3970/sdhm.2014.010.019

    Abstract The electromechanical impedance (EMI) method is one of the many nondestructive evaluation approaches proposed for the health monitoring of aerospace, civil, and mechanical structures. The method consists of attaching or embedding one or more wafer-type piezoelectric transducers (PZTs) to the system of interest, the host structure, and measuring certain electrical characteristics of the transducers. As these characteristics are also related to the impedance of the host structure, they can be used to infer the mechanical properties of the monitored structure. In the study presented in this paper, we utilize the EMI to monitor the quality… More >

  • Open Access

    ARTICLE

    Structure Health Monitoring (SHM) System Trade Space Analysis

    Salman A. Albinali1, David R. Jacques2

    Structural Durability & Health Monitoring, Vol.10, No.1, pp. 1-17, 2014, DOI:10.3970/sdhm.2014.010.001

    Abstract An analytic approach to exploring the tradespace associated with Structural Health Monitoring (SHM) systems is presented. Modeling and simulation of the life cycle of a legacy aircraft and the expected operational and maintenance events that could occur is shown. A focus on the SHM system detection of a significant crack length and the possibility of False Alarm (FA), miss detection and mishap events is investigated. The modeling approach allows researchers to explore the tradespace associated with safe and critical crack lengths, sensor thresholds, scheduled maintenance intervals, falsely triggered maintenance actions, and mishaps due to missed… More >

  • Open Access

    ARTICLE

    Finite Element Analysis of Three-dimensional Periodic Notched Plates

    R. Afshar1, F. Berto1,2

    Structural Durability & Health Monitoring, Vol.9, No.4, pp. 349-364, 2013, DOI:10.32604/sdhm.2013.009.349

    Abstract Using the finite element method, three-dimensional models of a number of periodic blunt and sharp notches subjected to tension loading are carried out. The aim of this research is to investigate the thickness effect on the location of maximum stress and notch stress intensity factor (NSIF) of corresponding blunt and sharp periodic notches respectively. With this aim, a wide range of notch geometries are examined. While for two-dimensional plates weakened by periodic notches some results are available in the literature, this paper first faces with the problem of three-dimensional cases. The total of about 100 More >

  • Open Access

    ARTICLE

    Damage Detection of Cyclically Loaded Concrete Shear Wall using EMI Technique

    A. Likhith Reddy1, Shirleen Charles1, C. Bharathi Priya2, G.V. Rama Rao2, N. Gopalakrishnan3,4 , A. Rama Mohan Rao3

    Structural Durability & Health Monitoring, Vol.9, No.4, pp. 325-347, 2013, DOI:10.32604/sdhm.2013.009.325

    Abstract Details of the investigations on an unexplored application of Electro Mechanical Impedance (EMI) technique using smart piezoelectric (PZT) sensors for damage detection of concrete shear wall structures under crack opening and closing is presented in this paper. The behavior and the ability of this method to detect damages, in a heterogeneous quasi-brittle material is studied for its effective utilization in structural health monitoring. The paper discusses the experimental investigations conducted on a concrete shear wall using PZT patches. Conductance data is acquired at different applied lateral displacements of shear wall. Damage index is calculated using More >

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