GUOQIANG HOU^1,2,#, XINHANG XU^2,#, WEIXING HU^1,*

Oncology Research, Vol.32, No.4, pp. 727-736, 2024, DOI:10.32604/or.2023.043391

Abstract Primary tumors of the central nervous system (CNS) are classified into over 100 different histological types. The most common type of glioma is derived from astrocytes, and the most invasive glioblastoma (WHO IV) accounts for over 57% of these tumors. Glioblastoma (GBM) is the most common and fatal tumor of the CNS, with strong growth and invasion capabilities, which makes complete surgical resection almost impossible. Despite various treatment methods such as surgery, radiotherapy, and chemotherapy, glioma is still an incurable disease, and the median survival time of patients with GBM is shorter than 15 months. Thus, molecular mechanisms of GBM… More >

KUNLUN LI¹, DANDAN LI², BARBOD HAFEZ^3,*, MOUNIR M. SALEM BEKHIT⁴, YOUSEF A. BIN JARDAN⁴, FARS KAED ALANAZI⁴, EHAB I. TAHA⁴, SAYED H. AUDA⁴, FAIQAH RAMZAN^5,*, MUHAMMAD JAMIL⁶

Oncology Research, Vol.32, No.4, pp. 737-752, 2024, DOI:10.32604/or.2023.042925

Abstract Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that carries a substantial risk of morbidity and mortality. The MMP family assumes a crucial role in tumor invasion and metastasis. This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the present study to analyze MMP… More >

WEN GE^1,2,#, YA LI^1,2,#, YUTING RUAN^1,2, NINGXIA WU^1,2, PEI MA^3,4, TONGPENG XU^3,4, YONGQIAN SHU^3,4, YINGWEI WANG^1,2, WEN QIU^1,2, CHENHUI ZHAO^3,4,*

Oncology Research, Vol.32, No.4, pp. 625-641, 2024, DOI:10.32604/or.2023.031053

Abstract The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer (NSCLC). Although researchers have disclosed that interleukin 17 (IL-17) can increase matrix metalloproteinases (MMPs) induction causing NSCLC cell metastasis, the underlying mechanism remains unclear. In the study, we found that IL-17 receptor A (IL-17RA), p300, p-STAT3, Ack-STAT3, and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17. p300, STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3, Ack-STAT3 and MMP19 level as well as the cell migration and invasion. Mechanism investigation revealed that STAT3 and p300 bound… More > Graphic Abstract

LU ZHANG^*, JINGUO CHU^*, YUSHAN YU

Oncology Research, Vol.32, No.4, pp. 703-716, 2024, DOI:10.32604/or.2023.030988

Abstract Background: Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs (ARLncRNAs) on the prognosis of hepatocellular carcinoma (HCC). Methods: We analyzed 371 HCC samples from TCGA, identifying expression networks of ARLncRNAs using autophagy-related genes. Screening for prognostically relevant ARLncRNAs involved univariate Cox regression, Lasso regression, and multivariate Cox regression. A Nomogram was further employed to assess the reliability of Riskscore, calculated from the signatures of screened ARLncRNAs, in predicting outcomes. Additionally, we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis, using consensus clustering to identify subgroups… More >

JIJIE XIAO¹, HONG XIAO², YUJUN CAI³, JIANWEI LIAO¹, JUE LIU¹, LIN YAO¹, SHAOLIN LI^1,*

Oncology Research, Vol.32, No.4, pp. 691-702, 2024, DOI:10.32604/or.2023.030767

Abstract Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the photosensitizer Chlorin e6 (Ce6) and CD47 monoclonal antibodies (aCD47), to deliver synergistic photodynamic and immunotherapy of osteosarcoma. On laser irradiation, Ce6 can generate reactive oxygen species (ROS) to… More > Graphic Abstract

A. Valan Arasu^a,*, Agus P. Sasmito^b,†, Arun S. Mujumdar^b

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-7, 2011, DOI:10.5098/hmt.v2.4.3005

Abstract The heat transfer enhancement of paraffin wax, a cheap and widely used latent heat thermal energy storage material, using nanoparticles is investigated. The effects of nanoparticle volume fraction on both the melting and solidification rates of paraffin wax are analysed and compared for Al₂O₃ and CuO nanoparticles. Present results show that dispersing nanoparticles in smaller volumetric fractions increase the heat transfer rate. The enhancement in thermal performance of paraffin wax is greater for Al₂O₃ compared with that for CuO nanoparticles. More >

Antti Lehtinen^a, Reijo Karvinen^b,∗

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-6, 2011, DOI:10.5098/hmt.v2.4.3004

Abstract Analytical solutions for three different flat plate conjugate heat transfer cases are presented. The cases are as follows:transient heat transfer of a thin plate with uniform heat generation; the Luikov problem in which one plate surface is kept in a constant temperature and the other one is cooled by forced convection ; and a modified Luikov problem with heat generation on one surface and convection on both surfaces of the plate. All the cases are solved for both laminar and turbulent flows with P r ≥ 1. The solutions in the paper are based on the superposition principle and analytical… More >

Muthasim Fahmy^†, Zhifa Sun

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-14, 2011, DOI:10.5098/hmt.v2.4.3003

Abstract A gas-liquid solute transfer process initiated in a closed vessel can exhibit Rayleigh-Bénard-Marangoni (RBM) convection enhanced mass transfer. For short exposure times experimental and theoretical results demonstrate that for deep liquid systems prior to solute penetration across the depth of the fluid, the stability thresholds of the system decreases with time. For thin liquid layers at longer exposure times the mass transfer enhancement under RBM convection can be affected in two ways: (1) solute penetration to the bottom liquid-solid boundary causing a departure from a penetration type concentration profile; (2) solute penetration to the top gas-solid boundary in the gas… More >

Cheng-Kang Guan, James F. Klausner^*, Renwei Mei

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-6, 2011, DOI:10.5098/hmt.v2.4.3002

Abstract Pool boiling critical heat flux (CHF) has been measured for pentane, hexane, methanol, FC-72, FC-87, and R113 on a 25.4 mm diameter smooth brass horizontal surface at five different reduced pressures ranging from 0.01to 0.24. The CHF data are compared with various established CHF models as well as the new mechanistic CHF lift-off model recently proposed by the authors. The dependence of CHF on pressure is examined, and it is found that the lift-off model gives a reasonably good prediction of changes in CHF with step changes in the reduced pressure. The R113 and FC-72 boiling curves suggest that a… More >

Morteza Eslamian^*

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-20, 2011, DOI:10.5098/hmt.v2.4.3001

Abstract Recent advances in thermodiffusion (Soret effect) in binary and higher multicomponent liquid mixtures are reviewed. The mixtures studied include the hydrocarbon, associating, molten metal and semiconductor, polymer, and DNA mixtures. The emphasis is placed on the theoretical works, particularly models based on the nonequilibrium thermodynamics, although other approaches such as the statistical, kinetic and hydrodynamic approaches are discussed as well. For each mixture, the major theoretical and experimental works are discussed and the research trends and challenges are addressed. Some of the challenges include a need for combining various methods to develop a comprehensive theoretical model or at least to… More >