Open Access

CASE REPORT

Primary signet-ring cell carcinoma of the prostate

Yoh Matsuoka^1,3, Gaku Arai¹, Hisashi Ishimaru¹, Kentaro Takagi¹, Yuji Ito²

1 Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan
2 Department of Pathology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan
3 Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Address correspondence to Dr. Yoh Matsuoka, Department of Urology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

Canadian Journal of Urology 2007, 14(6), 3764-3766.

Abstract

We report a rare case of primary signet-ring cell carcinoma of the prostate in an advanced stage. A 62-year-old man with serum level of prostate-specific antigen at 364.70 ng/ml was diagnosed as having cT4N1M1c prostatic signet-ring cell carcinoma of Gleason score 5 + 4 = 9. Immunohistochemical examination demonstrated cytoplasmic immunoreactivity to prostate-specific antigen in signet-ring cancer cells. The intracytoplasmic vacuoles in the signet-ring cells showed mucin production with a positive staining with periodic acid-Schiff. Although the patient received hormonal therapy, the disease progressed and lead to death 15 months after the diagnosis. The clinical and immunohistochemical characteristics of this malignancy are also reviewed.

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