Open Access

CASE REPORT

Vesicoenteric, vesicovaginal, vesicocutaneous fistula –an unusual complication with intravesical mitomycin

Pankaj P. Dangle, Wenle Paul Wang, Kamal S. Pohar

James Cancer Hospital and Solove Research Institute, Ohio State University and Comprehensive Cancer Center, Columbus, Ohio, USA
Address correspondence to Dr.Pankaj P. Dangle, James Cancer Hospital and Solove Research Institute, Ohio State University and Comprehensive Cancer Center, 324 Tzagournis Research Facilities, 420 West 12^th Avenue, Columbus, Ohio 43210 USA

Canadian Journal of Urology 2008, 15(5), 4269-4272.

Abstract

Intravesical instillation of mitomycin C is a routine practice for treatment of superfi cial transitional cell carcinoma of bladder. Despite usual precautions serious side effects like fi stulation can occur with diverse presentation as illustrated by this report. The pathology demonstrates a dense necrotic and massive infl ammatory reaction in the peri vesical tissue following the extravasation of an intravesically administered chemotherapeutic agent. The severe infl ammatory tissue response and the necrotic effect associated with the extravasated chemotherapeutic agent could potentially lead to local sepsis with a subsequent fi stula formation.

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