Numerical Investigation of an Idealized Total Cavopulmonary Connection Physiology Assisted by the Axial Blood Pump With and Without Diffuser
- Zhenxin Zhao1,#, Tong Chen2,#, Xudong Liu3, Shengzhang Wang2,4,*, Haiyan Lu5,*
1 Skynor Medical (Shanghai) Medical Co., Ltd., Shanghai, 201318, China
2 Academy of Engineering & Technology, Fudan University, Shanghai, 200433, China
3 Shanghai MicroPort Medical (Group) Co., Ltd., Shanghai, 201203, China
4 Department of Aeronautics and Astronautics, Fudan University, Shanghai, 200433, China
5 Interventional Ultrasound Division of VIP Clinic Department, Dongfang Hospital Affiliated to Tongji University, Shanghai, 200120, China
∗ Corresponding Authors: Shengzhang Wang. Email:
; Haiyan Lu. Email: 
# Zhenxin Zhao and Tong Chen contributed equally to this work
(This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
2 Academy of Engineering & Technology, Fudan University, Shanghai, 200433, China
3 Shanghai MicroPort Medical (Group) Co., Ltd., Shanghai, 201203, China
4 Department of Aeronautics and Astronautics, Fudan University, Shanghai, 200433, China
5 Interventional Ultrasound Division of VIP Clinic Department, Dongfang Hospital Affiliated to Tongji University, Shanghai, 200120, China
∗ Corresponding Authors: Shengzhang Wang. Email:
# Zhenxin Zhao and Tong Chen contributed equally to this work
(This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
Received 17 August 2020; Accepted 10 October 2020; Issue published 15 December 2020
Abstract
In order to improve the surgical treatment of the congenital heart
disease patient with single ventricle defect, two axial flow blood pumps, one
with diffuser and the other without diffuser, were designed and virtually
implanted into an idealized total cavopulmonary connection (TCPC) model
to form two types of Pump-TCPC physiological structure. Computational
fluid dynamics (CFD) simulations were performed to analyze the variations of
the hemodynamic characteristics, such as flow field, wall shear stress (WSS),
oscillatory shear index (OSI), relative residence time (RRT), between the two
Pump-TCPC models. Numerical results indicate that the Pump-TCPC with
diffuser has better flow field stability, less damage on endothelial cell of vessel
wall, and lower risk of vascular injury and thrombosis formation than that
without diffuser.
Keywords
Computational fluid dynamics; total cavopulmonary connection; axial flow blood pump; vascular damage; thrombosis probability
Cite This Article
Zhao, Z., Chen, T., Liu, X., Wang, S., Lu, H. (2020). Numerical Investigation of an Idealized Total Cavopulmonary Connection Physiology Assisted by the Axial Blood Pump With and Without Diffuser. CMES-Computer Modeling in Engineering & Sciences, 125(3), 1173–1184.
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