Open Access

ARTICLE

Numerical Investigation of an Idealized Total Cavopulmonary Connection Physiology Assisted by the Axial Blood Pump With and Without Diffuser

Zhenxin Zhao^1,#, Tong Chen^2,#, Xudong Liu³, Shengzhang Wang^2,4,*, Haiyan Lu^5,*
1 Skynor Medical (Shanghai) Medical Co., Ltd., Shanghai, 201318, China
2 Academy of Engineering & Technology, Fudan University, Shanghai, 200433, China
3 Shanghai MicroPort Medical (Group) Co., Ltd., Shanghai, 201203, China
4 Department of Aeronautics and Astronautics, Fudan University, Shanghai, 200433, China
5 Interventional Ultrasound Division of VIP Clinic Department, Dongfang Hospital Affiliated to Tongji University, Shanghai, 200120, China
∗ Corresponding Authors: Shengzhang Wang. Email: ; Haiyan Lu. Email:
# Zhenxin Zhao and Tong Chen contributed equally to this work
(This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)

Computer Modeling in Engineering & Sciences 2020, 125(3), 1173-1184. https://doi.org/10.32604/cmes.2020.013702

Received 17 August 2020; Accepted 10 October 2020; Issue published 15 December 2020

Abstract

In order to improve the surgical treatment of the congenital heart disease patient with single ventricle defect, two axial flow blood pumps, one with diffuser and the other without diffuser, were designed and virtually implanted into an idealized total cavopulmonary connection (TCPC) model to form two types of Pump-TCPC physiological structure. Computational fluid dynamics (CFD) simulations were performed to analyze the variations of the hemodynamic characteristics, such as flow field, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), between the two Pump-TCPC models. Numerical results indicate that the Pump-TCPC with diffuser has better flow field stability, less damage on endothelial cell of vessel wall, and lower risk of vascular injury and thrombosis formation than that without diffuser.

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Keywords

Computational fluid dynamics; total cavopulmonary connection; axial flow blood pump; vascular damage; thrombosis probability

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