Special Issue "Computer Methods in Bio-mechanics and Biomedical Engineering"

Submission Deadline: 30 October 2019 (closed)

• OPEN ACCESS    
  ARTICLE
• Prediction of Intrinsically Disordered Proteins Based on Deep Neural Network-ResNet18
• Jie Zhang, Jiaxiang Zhao^*, Pengchang Xu
• CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 905-917, 2022, DOI:10.32604/cmes.2022.019097
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Accurately, reliably and rapidly identifying intrinsically disordered (IDPs) proteins is essential as they often play important roles in various human diseases; moreover, they are related to numerous important biological activities. However, current computational methods have yet to develop a network that is sufficiently deep to make predictions about IDPs and demonstrate an improvement in performance. During this study, we constructed a deep neural network that consisted of five identical variant models, ResNet18, combined with an MLP network, for classification. Resnet18 was applied for the first time as a deep model for predicting IDPs, which allowed the extraction of information from… More
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• OPEN ACCESS    
  ARTICLE
• Fast and Accurate Thoracic SPECT Image Reconstruction
• Afef Houimli^1,*, IssamBen Mhamed², Bechir Letaief^1,3,4, Dorra Ben-Sellem^1,3,4
• CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 881-904, 2022, DOI:10.32604/cmes.2022.016705
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract In Single-Photon Emission Computed Tomography (SPECT), the reconstructed image has insufficient contrast, poor resolution and inaccurate volume of the tumor size due to physical degradation factors. Generally, nonstationary filtering of the projection or the slice is one of the strategies for correcting the resolution and therefore improving the quality of the reconstructed SPECT images. This paper presents a new 3D algorithm that enhances the quality of reconstructed thoracic SPECT images and reduces the noise level with the best degree of accuracy. The suggested algorithm is composed of three steps. The first one consists of denoising the acquired projections using the… More
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• OPEN ACCESS    
  ARTICLE
• Identification of Denatured Biological Tissues Based on Improved Variational Mode Decomposition and Autoregressive Model during HIFU Treatment
• Bei Liu¹, Xian Zhang^2,*
• CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.3, pp. 1547-1563, 2022, DOI:10.32604/cmes.2022.018130
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract During high-intensity focused ultrasound (HIFU) treatment, the accurate identification of denatured biological tissue is an important practical problem. In this paper, a novel method based on the improved variational mode decomposition (IVMD) and autoregressive (AR) model was proposed, which identified denatured biological tissue according to the characteristics of ultrasonic scattered echo signals during HIFU treatment. Firstly, the IVMD method was proposed to solve the problem that the VMD reconstruction signal still has noise due to the limited number of intrinsic mode functions (IMF). The ultrasonic scattered echo signals were reconstructed by the IVMD to achieve denoising. Then, the AR model… More
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• OPEN ACCESS    
  ARTICLE
• Adaptive Virtual Source Imaging Using the Sequence Intensity Factor: Simulation and Experimental Study
• Chichao Zheng, Yazhong Wang, Yadan Wang^*, Qing He, Hu Peng
• CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.1, pp. 397-413, 2022, DOI:10.32604/cmes.2022.016308
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Virtual source (VS) imaging has been proposed to improve image resolution in medical ultrasound imaging. However, VS obtains a limited contrast due to the non-adaptive delay-and-sum (DAS) beamforming. To improve the image contrast and provide an enhanced resolution, adaptive weighting algorithms were applied in VS imaging. In this paper, we proposed an adjustable generalized coherence factor (aGCF) for the synthetic aperture sequential beamforming (SASB) of VS imaging to improve image quality. The value of aGCF is adjusted by a sequence intensity factor (SIF) that is defined as the ratio between the effective low resolution scan lines (LRLs) intensity and total… More
•   Views:497       Downloads:383        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Predicting Genotype Information Related to COVID-19 for Molecular Mechanism Based on Computational Methods
• Lejun Gong^1,2,*, Xingxing Zhang¹, Li Zhang³, Zhihong Gao⁴
• CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.1, pp. 31-45, 2021, DOI:10.32604/cmes.2021.016622
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Novel coronavirus disease 2019 (COVID-19) is an ongoing health emergency. Several studies are related to COVID-19. However, its molecular mechanism remains unclear. The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods. This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning. The method obtains seed genes based on prior knowledge. Candidate genes are mined from biomedical literature. The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate genes. Furthermore, the results of… More
•   Views:973       Downloads:787        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Implementing Delay Multiply and Sum Beamformer on a Hybrid CPU-GPU Platform for Medical Ultrasound Imaging Using OpenMP and CUDA
• Ke Song^1,*, Paul Liu², Dongquan Liu³
• CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.3, pp. 1133-1150, 2021, DOI:10.32604/cmes.2021.016008
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract A novel beamforming algorithm named Delay Multiply and Sum (DMAS), which excels at enhancing the resolution and contrast of ultrasonic image, has recently been proposed. However, there are nested loops in this algorithm, so the calculation complexity is higher compared to the Delay and Sum (DAS) beamformer which is widely used in industry. Thus, we proposed a simple vector-based method to lower its complexity. The key point is to transform the nested loops into several vector operations, which can be efficiently implemented on many parallel platforms, such as Graphics Processing Units (GPUs), and multi-core Central Processing Units (CPUs). Consequently, we… More
•   Views:727       Downloads:976        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Bioprosthetic Valve Size Selection to Optimize Aortic Valve Replacement Surgical Outcome: A Fluid-Structure Interaction Modeling Study
• Caili Li¹, Dalin Tang^2,*,3, Jing Yao^4,*, Christopher Baird⁵, Haoliang Sun⁶, Chanjuan Gong⁷, Luyao Ma⁶, Yanjuan Zhang⁴, Liang Wang², Han Yu², Chun Yang⁸, Yongfeng Shao⁶
• CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.1, pp. 159-174, 2021, DOI:10.32604/cmes.2021.014580
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Aortic valve replacement (AVR) remains a major treatment option for patients with severe aortic valve disease. Clinical outcome of AVR is strongly dependent on implanted prosthetic valve size. Fluid-structure interaction (FSI) aortic root models were constructed to investigate the effect of valve size on hemodynamics of the implanted bioprosthetic valve and optimize the outcome of AVR surgery. FSI models with 4 sizes of bioprosthetic valves (19 (No. 19), 21 (No. 21), 23 (No. 23) and 25 mm (No. 25)) were constructed. Left ventricle outflow track flow data from one patient was collected and used as model flow conditions. Anisotropic Mooney–Rivlin… More
•   Views:1459       Downloads:1022        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Classifying Abdominal Fat Distribution Patterns by Using Body Measurement Data
• Jingjing Sun¹, Bugao Xu^1,2,*, Jane Lee³, Jeanne H. Freeland-Graves³
• CMES-Computer Modeling in Engineering & Sciences, Vol.126, No.3, pp. 1189-1202, 2021, DOI:10.32604/cmes.2021.014405
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract This study aims to explore new categorization that characterizes the distribution clusters of visceral and subcutaneous adipose tissues (VAT and SAT) measured by magnetic resonance imaging (MRI), to analyze the relationship between the VAT-SAT distribution patterns and the novel body shape descriptors (BSDs), and to develop a classifier to predict the fat distribution clusters using the BSDs. In the study, 66 male and 54 female participants were scanned by MRI and a stereovision body imaging (SBI) to measure participants’ abdominal VAT and SAT volumes and the BSDs. A fuzzy c-means algorithm was used to form the inherent grouping clusters of… More
•   Views:1207       Downloads:969        Download PDF

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• OPEN ACCESS    
  ARTICLE
• An Efficient Algorithm Based on Spectrum Migration for High Frame Rate Ultrasound Imaging
• Shuai Feng¹, Liu Jin¹, Yadan Wang¹, Wei Zhao^1,2, Hu Peng^1,*, Heyuan Qiao¹
• CMES-Computer Modeling in Engineering & Sciences, Vol.126, No.2, pp. 739-754, 2021, DOI:10.32604/cmes.2021.014027
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract The high frame rate (HFR) imaging technique requires only one emission event for imaging. Therefore, it can achieve ultrafast imaging with frame rates up to the kHz regime, which satisfies the frame rate requirements for imaging moving tissues in scientific research and clinics. Lu’s Fourier migration method is based on a non-diffraction beam to obtain HFR images and can improve computational speed and efficiency. However, in order to obtain high-quality images, Fourier migration needs to make full use of the spectrum of echo signals for imaging, which requires a large number of Fast Fourier Transform (FFT) points and increases the… More
•   Views:1359       Downloads:1213        Download PDF

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• OPEN ACCESS    
  ARTICLE
• ALCencryption: A Secure and Efficient Algorithm for Medical Image Encryption
• Jiao Ge^1,2,*
• CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 1083-1100, 2020, DOI:10.32604/cmes.2021.013039
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract With the rapid development of medical informatization and the popularization of digital imaging equipment, DICOM images contain the personal privacy of patients, and there are security risks in the process of storage and transmission, so it needs to be encrypted. In order to solve the security problem of medical images on mobile devices, a safe and efficient medical image encryption algorithm called ALCencryption is designed. The algorithm first analyzes the medical image and distinguishes the color image from the gray image. For gray images, the improved Arnold map is used to scramble them according to the optimal number of iterations,… More
•   Views:5834       Downloads:2043       Cited by:2        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Numerical Investigation of an Idealized Total Cavopulmonary Connection Physiology Assisted by the Axial Blood Pump With and Without Diffuser
• Zhenxin Zhao^1,#, Tong Chen^2,#, Xudong Liu³, Shengzhang Wang^2,4,*, Haiyan Lu^5,*
• CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 1173-1184, 2020, DOI:10.32604/cmes.2020.013702
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract In order to improve the surgical treatment of the congenital heart disease patient with single ventricle defect, two axial flow blood pumps, one with diffuser and the other without diffuser, were designed and virtually implanted into an idealized total cavopulmonary connection (TCPC) model to form two types of Pump-TCPC physiological structure. Computational fluid dynamics (CFD) simulations were performed to analyze the variations of the hemodynamic characteristics, such as flow field, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), between the two Pump-TCPC models. Numerical results indicate that the Pump-TCPC with diffuser has better flow field stability,… More
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• OPEN ACCESS    
  ARTICLE
• Numerical Simulation of Bone Remodeling Coupling the Damage Repair Process in Human Proximal Femur
• Chuanyong Qu^*, Hui Yuan
• CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.2, pp. 829-847, 2020, DOI:10.32604/cmes.2020.012407
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Microdamage is produced in bone tissue under the long-term effects of physiological loading, as well as age, disease and other factors. Bone remodeling can repair microdamage, otherwise this damage will undermine bone quality and even lead to fractures. In this paper, the damage variable was introduced into the remodeling algorithm. The new remodeling algorithm contains a quadratic term that can simulate reduction in bone density after large numbers of loading cycles. The model was applied in conjunction with the 3D finite element method (FEM) to the remodeling of the proximal femur. The results showed that the initial accumulation of fatigue… More
•   Views:1592       Downloads:1400        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Soft Tissue Deformation Model Based on Marquardt Algorithm and Enrichment Function
• Xiaorui Zhang^1,2,*, Xuefeng Yu¹, Wei Sun², Aiguo Song³
• CMES-Computer Modeling in Engineering & Sciences, Vol.124, No.3, pp. 1131-1147, 2020, DOI:10.32604/cmes.2020.09735
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract In order to solve the problem of high computing cost and low simulation accuracy caused by discontinuity of incision in traditional meshless model, this paper proposes a soft tissue deformation model based on the Marquardt algorithm and enrichment function. The model is based on the element-free Galerkin method, in which Kelvin viscoelastic model and adjustment function are integrated. Marquardt algorithm is applied to fit the relation between force and displacement caused by surface deformation, and the enrichment function is applied to deal with the discontinuity in the meshless method. To verify the validity of the model, the Sensable Phantom Omni… More
•   Views:2263       Downloads:1818        Download PDF

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• OPEN ACCESS    
  ARTICLE
• A Geometrical Approach to Compute Upper Limb Joint Stiffness
• Davide Piovesan^{1, *}, Roberto Bortoletto²
• CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.1, pp. 23-47, 2020, DOI:10.32604/cmes.2020.09231
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Exoskeletons are designed to control the forces exerted during the physical coupling between the human and the machine. Since the human is an active system, the control of an exoskeleton requires coordinated action between the machine and the load so to obtain a reciprocal adaptation. Humans in the control loop can be modeled as active mechanical loads whose stiffness is continuously changing. The direct measurement of human stiffness is difficult to obtain in real-time, thus posing a significant limitation to the design of wearable robotics controllers. Electromyographic (EMG) recordings can provide an indirect estimation of human muscle force and stiffness,… More
•   Views:2744       Downloads:2057        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Automatic Sleep Staging Algorithm Based on Random Forest and Hidden Markov Model
• Junbiao Liu^{1, 6}, Duanpo Wu^{2, 3}, Zimeng Wang², Xinyu Jin^{1, *}, Fang Dong⁴, Lurong Jiang⁵, Chenyi Cai⁶
• CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.1, pp. 401-426, 2020, DOI:10.32604/cmes.2020.08731
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract In the field of medical informatics, sleep staging is a challenging and timeconsuming task undertaken by sleep experts. According to the new standard of the American Academy of Sleep Medicine (AASM), the stages of sleep are divided into wakefulness (W), rapid eye movement (REM) and non-rapid eye movement (NREM) which includes three sleep stages (N1, N2 and N3) that describe the depth of sleep. This study aims to establish an automatic sleep staging algorithm based on the improved weighted random forest (WRF) and Hidden Markov Model (HMM) using only the features extracted from double-channel EEG signals. The WRF classification model… More
•   Views:2927       Downloads:2171       Cited by:1        Download PDF

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• OPEN ACCESS    
  ARTICLE
• A Joint Delay-and-Sum and Fourier Beamforming Method for High Frame Rate Ultrasound Imaging
• Wei Zhao^{1, 2}, Shuai Feng¹, Yadan Wang¹, Yuanguo Wang¹, Zhihui Han¹, Hu Peng^{1, *}
• CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.1, pp. 427-440, 2020, DOI:10.32604/cmes.2020.09387
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract Frame rate is an important metric for ultrasound imaging systems, and high frame rates (HFR) benefit moving-target imaging. One common way to obtain HFR imaging is to transmit a plane wave. Delay-and-sum (DAS) beamformer is a conventional beamforming algorithm, which is simple and has been widely implemented in clinical application. Fourier beamforming is an alternative method for HFR imaging and has high levels of imaging efficiency, imaging speed, and good temporal dynamic characteristics. Nevertheless, the resolution and contrast performance of HFR imaging based on DAS or Fourier beamforming are insufficient due to the single plane wave transmission. To address this… More
•   Views:2810       Downloads:1962        Download PDF

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• OPEN ACCESS    
  ARTICLE
• Grading Method for Hypoxic-Ischemic Encephalopathy Based on Neonatal EEG
• Jingmin Guo¹, Xiu Cheng¹, Duanpo Wu^{2, 3, *}
• CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.2, pp. 721-741, 2020, DOI:10.32604/cmes.2020.07470
• （This article belongs to this Special Issue: Computer Methods in Bio-mechanics and Biomedical Engineering)
• Abstract The grading of hypoxic-ischemic encephalopathy (HIE) contributes to the clinical decision making for neonates with HIE. In this paper, an automated grading method based on electroencephalogram (EEG) data is proposed to describe the severity of HIE infants, namely mild asphyxia, moderate asphyxia and severe asphyxia. The automated grading method is based on a multi-class support vector machine (SVM) classifier, and the input features of SVM classifier include long-term features which are extracted by decomposing the EEG data into different 64 s epoch data and short-term features which are extracted by segmenting the 64 s epoch data into 8 s epoch… More
•   Views:3480       Downloads:1987       Cited by:2        Download PDF

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