Meshless Generalized Finite Difference Method and Human Carotid Atherosclerotic Plaque Progression Simulation Using Multi-Year MRI Patient-Tracking Data
Chun Yang1, Dalin Tang2, Chun Yuan3, William Kerwin2, Fei Liu3, Gador Canton3, Thomas S. Hatsukami3,4, Satya Atluri5
CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.2, pp. 95-108, 2008, DOI:10.3970/cmes.2008.028.095
Abstract Atherosclerotic plaque rupture and progression have been the focus of intensive investigations in recent years. Plaque rupture is closely related to most severe cardiovascular syndromes such as heart attack and stroke. A computational procedure based on meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data was introduced to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Participating patients were scanned three times (T1,T2, and T3, at intervals of about 18 months) to obtain plaque progression data. Vessel wall thickness (WT) changes were used as the measure for plaque progression. Since there was insufficient… More >
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