Open Access

REVIEW

When wrinkles appear on the immune system can it be reversed?

Hiba Sibaii¹, Salwa Refat El-Zayat¹, Mona Khalil²

1 Medical Physiology Department, National Research Centre (NRC), Egypt
2 Department of Basic Sciences, Biology Division, Deanship of Preparatory Year, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Saudi Arabia

* Corresponding Author: H. Sibaii,

European Cytokine Network 2020, 31(1), 1-17. https://doi.org/10.1684/ecn.2020.0441

Accepted 22 November 2019;

Abstract

During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed ‘immunosenescence’ characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells decline, resulting in an increase in the susceptibility to infection, development of cancer, as well as autoimmune disorders. The study of age-related changes in immune function is an important area of investigation. In this review, the function of the immune system during aging, as well as the different ways to rejuvenate the aging immune system, is explored, as medical intervention, balanced nutrition, and a healthy life style will be discussed.

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Keywords

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