Open Access

ORIGINAL ARTICLE

Serum levels of nesfatin-1 and irisin in obese children

Eda Dokumacioglu¹, Hatice Iskender¹, Arzu Sahin², Emine Yurdakul Erturk³, Ozgur Kaynar⁴

1 Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin C¸ oruh University, Artvin, Turkey
2 Arzu Sahin, Department of Physiology, Faculty of Medicine, Us¸ak University, Us¸ak, Turkey
3 Emine Yurdakul Erturk, Faculty of Medicine, Pediatric Health and Diseases Department, Ordu University, Ordu, Turkey
4 Ozgur Kaynar, Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey

* Corresponding Author: Eda Dokumacioglu,

European Cytokine Network 2020, 31(1), 39-43. https://doi.org/10.1684/ecn.2020.0444

Abstract

Background: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomitant and rapid increase in the prevalence of childhood obesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. Methods: The present study was carried out with a total of 62 children, including 32 obese children diagnosed between June 2017 and October 2017 and 30 healthy children. Serum nesfatin-1, irisin, SOD, MDA, fasting blood glucose, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, aspartate amino transferase (AST), alanine amino transferase (ALT), blood urea nitrogen (BUN), C-reactive protein (CRP), calcium (Ca), sodium (Na), potassium (P), chromium (Cr), ferritin, and vitamin B12 data were collected for each patient. Results: In our study, mean nesfatin-1 and SOD values of the obesity group were lower than those of the control group (p < 0.05, p < 0.001), whereas irisin and MDA values were higher than those of the control group (p < 0.001). Conclusion: Childhood obesity is still a significant global problem, despite increased social awareness and numerous preventive healthcare interventions. We believe that all the prospective studies to be carried out to evaluate the relationship between obesity-irisin-nesfatin-1 triad, will make positive contributions to treatment of obesity.

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Keywords

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