Open Access
ARTICLE
Magnetic mitohormesis: A non-invasive therapy for inflammatory disorders?
ALFREDO FRANCO-OBREGÓN*
Department of Surgery, Yong Loo Lin School of Medicine, Institute of Health Technology and Innovation, iHealthtech, Biolonic Currents Electromagnetic
Pulsing Systems Laboratory, BICEPS, Healthy Longevity Translational Research Programme, NUS Centre for Cancer Research, National University of
Singapore, Singapore
* Corresponding Author: Alfredo Franco-Obregón,
BIOCELL 2023, 47(2), 239-244. https://doi.org/10.32604/biocell.2023.025357
Received 07 July 2022; Accepted 25 August 2022; Issue published 18 November 2022
Abstract
An organism’s survival depends on its ability to adapt to stress. Mitochondria are the cellular integrators of
environmental stressors that ultimately translate their responses at the organismal level, and are thus central to the
process whereby organisms adapt to their respective environments. Mitochondria produce molecular energy via
oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their
environment. Reactive oxygen species (ROS) are by-products of oxidative phosphorylation that can be either
beneficial or damaging, depending on the context; ROS are hence both the conveyors of environmental stress as well
as cellular “adaptogens”. Mitohormesis refers to the process whereby low levels of oxidative stress spur survival
adaptations, whereas excessive levels stymie survival. Low energy and frequency pulsing electromagnetic fields have
been recently shown capable of stimulating mitochondrial respiration and ROS production and instilling
mitohormetic survival adaptations, similarly to, yet independently of, exercise, opening avenues for the future
development of Magnetic Mitohormetic interventions for the improvement of human health. This viewpoint explores
the possibilities and nuances of magnetic-based therapies as a form of clinical intervention to non-invasively activate
magnetic mitohormesis for the management of chronic diseases.
Keywords
Cite This Article
FRANCO-OBREGÓN, A. (2023). Magnetic mitohormesis: A non-invasive therapy for inflammatory disorders?.
BIOCELL, 47(2), 239–244. https://doi.org/10.32604/biocell.2023.025357