Submit

Login Login

Register Register

Home / Journals / BIOCELL / Online First / doi:10.32604/biocell.2025.060565
Journal Menu
Special Issues
Table of Content

All issues

Online First

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

SAIB Annual Meetings

Open Access

REVIEW

The Pathophysiologic Role of Oxidative Stress in Mitotic Cell Division

Nathan Isaac Dibal1,*, Martha Orendu Oche Attah1,2
1 Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Maiduguri, 600233, Nigeria
2 Faculty of Medicine, Cyprus International University, Nicosia, 1010, Cyprus
* Corresponding Author: Nathan Isaac Dibal. Email: email
(This article belongs to the Special Issue: Mitochondrial Dynamics and Oxidative Stress in Disease: Cellular Mechanisms and Therapeutic Targets)

BIOCELL https://doi.org/10.32604/biocell.2025.060565

Received 04 November 2024; Accepted 21 January 2025; Published online 17 February 2025

Abstract

Oxidative stress is characterized by elevated intracellular reactive oxygen species (ROS) levels. At physiological levels, ROS work as signaling molecules, helping cells go through the cell cycle normally and keeping their balance. They also balance several physiological processes. However, a shift in the delicate balance between antioxidants and ROS results in aberrant cell death and deleterious effects. Elevated ROS is implicated in many diseases and disorders like diabetes, autoimmune diseases, infertility, and cardiovascular disorders. The imbalance disrupts normal cellular functions, including cell division. ROS are important regulators of the cell cycle, exerting both favorable and harmful effects depending on their levels in the system, time of action, and cellular context. The present review article highlights the role of ROS as a predisposing factor of cell cycle arrest and its effect on various stages of the cell cycle. It also considers the role ROS plays in disorders that are caused by oxidative stress, presents the interplay between ROS and cell division and explores the therapeutic intervention beneficial in managing these disorders.

Keywords

Cell cycle; mitosis; oxidative stress; ROS

  • 386

    View

  • 99

    Download

  • 0

    Like

Related articles
Copyright© 2025 Tech Science Press
© 1997-2025 TSP (Henderson, USA) unless otherwise stated

Share Link