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Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats

MARLI APARECIDA DOS SANTOS PEREIRA, MARIA CLAÚDIA BAGATIN, JACQUELINE NELISIS ZANONI

Departament of Morphophysiological Sciences; State University of Maringá, Paraná, Brazil.
Address correspondence to: Dra. Marli Aparecida dos Santos Pereira. Departamento de Ciencias Morfofisiológicas, Universidade Estadual de Maringá. Av. Colombo 5790 Bloco H-79. CEP 87020900 Maringá, PR, BRASIL. Fax: (+55-44) 261 4340. E-mail: madspereira@uem.br

BIOCELL 2006, 30(2), 295-300. https://doi.org/10.32604/biocell.2006.30.295

Abstract

We assessed the ascorbic acid (AA) supplementation on the myenteric neurons in the duodenum of rats. Fifteen rats with 90 days of age were divided into three groups: control (C), diabetics (D) and ascorbic acid treated diabetics (DA). After 120 days of daily treatment with AA, the duodenum was submitted to the NADH-diaphorase (NADH-d) histochemical technique, which allowed us to evaluate the neuronal density in an area of 8.96 mm2 for each duodenum, and also to measure the cellular profile area of 500 neurons per group. The supplementation promoted an increase on AA levels. The neuronal density (p <0.05) was higher in the group DA when compared to group D. There were no significant differences in the neuronal areas, when we compared groups C (204 ± 16.5) and D (146.3 ± 35.84) to groups D and DA (184.5 ± 5.6) (p> 0.05). The AA-supplementation avoided the density reduction of the NADHd myenteric neurons in the duodenum of diabetic rats.

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APA Style
PEREIRA, M.A.D.S., BAGATIN, M.C., ZANONI, J.N. (2006). Effects of the ascorbic acid supplementation on nadh-diaphorase myenteric neurons in the duodenum of diabetic rats. BIOCELL, 30(2), 295-300. https://doi.org/10.32604/biocell.2006.30.295
Vancouver Style
PEREIRA MADS, BAGATIN MC, ZANONI JN. Effects of the ascorbic acid supplementation on nadh-diaphorase myenteric neurons in the duodenum of diabetic rats. BIOCELL . 2006;30(2):295-300 https://doi.org/10.32604/biocell.2006.30.295
IEEE Style
M.A.D.S. PEREIRA, M.C. BAGATIN, and J.N. ZANONI "Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats," BIOCELL , vol. 30, no. 2, pp. 295-300. 2006. https://doi.org/10.32604/biocell.2006.30.295

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