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An integrated analysis of mRNA-miRNA transcriptome data revealed hub regulatory networks in three genitourinary cancers

Mian LIU1, Xumeng ZHANG2, *
1 Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R.C
2 State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, P.R.C
* Address correspondence to: Xumeng Zhang, zhangxum@mail2. sysu.edu.cn

BIOCELL 2017, 41(1), 19-26. https://doi.org/10.32604/biocell.2017.41.019

Abstract

Bladder, kidney, prostate and testicular carcinoma are the top four genitourinary cancers in China. Here we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder (TCC), kidney (ccRCC) and testis (TGCT) to uncover their specific regulatory mechanisms. The gene expression profiles of GSE31617 were downloaded from GEO database, which contained 27 samples, including 10 TCC, 7 TGCT and 10 ccRCC. Specific up- and downregulated differentially expressed genes (DEGs) and differentially expressed microRNAs (DEmiRNAs) of each cancer were selected and target genes of DEmiRNAs were predicted. Gene interaction network of the shared genes and target genes of DEmiRNAs of each cancer was predicted by STRING and constructed by Cytoscape. In each cancer, we build regulatory networks of hub genes selected and conducted GO analysis of enriched genes. Furthermore, we chose four hub genes (SALL4, RHEB,CDC42 and TNN) for survival analysis in OncoLnc database, and they all had effects on the survival rate of another genitourinary cancer-kidney renal clear cell carcinoma (KIRC). In conclusion, the present study indicated that the identified hub genes promote our understanding of molecular mechanisms underlying the development of three genitourinary cancers, and might be used as molecular targets and diagnostic biomarkers for the treatment of them.

Keywords

Genitourinary cancers, Differentially expressed genes, Differentially expressed miRNAs, Hub genes

Cite This Article

LIU, M., ZHANG, X. (2017). An integrated analysis of mRNA-miRNA transcriptome data revealed hub regulatory networks in three genitourinary cancers. BIOCELL, 41(1), 19–26.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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