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Elevated nuclear phospho-eIF4E body levels are associated with tumor progression and poor prognosis for acute myeloid leukemia

HONG ZHOU1,*, XIAOFENG JIA1,2, FAN YANG1

1 Department of Hematology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China
2 College of Life Sciences, China Jiliang University, Hangzhou, 310018, China

* Address correspondence to: Hong Zhou, email

BIOCELL 2021, 45(3), 711-722. https://doi.org/10.32604/biocell.2021.014193

Abstract

Uncontrolled proliferation is a hallmark of cancer cells, yet the molecular mechanisms that contribute to this proliferation are unclear. Therapeutic treatment of cancer is suboptimal in many cases, with no accurate index by which to evaluate the success of treatment or patient prognosis. In this study, we explored the protein levels of nuclear phosphoeIF4E in acute myeloid leukemia (AML) cell lines and primary leukemia samples by Western blot and immunofluorescence and as well analyzed transcriptomes by RNA-seq. We found nuclear phospho-eIF4E, an exporter of oncogenic mRNAs, to be abundant in AML. Further, nuclear phospho-eIF4E abundance was significantly associated with tumor burden as well as the response of AML patients to chemotherapy. The results demonstrate “massive clustering and export of oncogenic mRNAs to the translation machinery” by highly abundant RNA-nuclear phospho-eIF4E bodies. This is an efficient mechanism that may drive the proliferation of cancer cells. Herein, nuclear phospho-eIF4E bodies were identified as potential markers of AML, which may be useful for prognosis and as targets for cancer therapy.

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APA Style
ZHOU, H., JIA, X., YANG, F. (2021). Elevated nuclear phospho-eif4e body levels are associated with tumor progression and poor prognosis for acute myeloid leukemia. BIOCELL, 45(3), 711-722. https://doi.org/10.32604/biocell.2021.014193
Vancouver Style
ZHOU H, JIA X, YANG F. Elevated nuclear phospho-eif4e body levels are associated with tumor progression and poor prognosis for acute myeloid leukemia. BIOCELL . 2021;45(3):711-722 https://doi.org/10.32604/biocell.2021.014193
IEEE Style
H. ZHOU, X. JIA, and F. YANG "Elevated nuclear phospho-eIF4E body levels are associated with tumor progression and poor prognosis for acute myeloid leukemia," BIOCELL , vol. 45, no. 3, pp. 711-722. 2021. https://doi.org/10.32604/biocell.2021.014193

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cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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