Open Access

ARTICLE

Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

JU HYUNG LEE¹, IL-KWON KIM^2,3, SANG WOO KIM^2,3, SOYEON LIM^2,3, SEAHYOUNG LEE^2,3, KI-CHUL HWANG^2,3, BYEONG-WOOK SONG^2,3,*

1 Graduate Program of Biomedical Engineering, Yonsei University, Seoul, 03722, Korea
2 Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangwon-do, 25601, Korea
3 Department for Medical Science, College of Medicine, Catholic Kwandong University, Gangwon-do, 25601, Korea

* Corresponding Author: Byeong-Wook Song,

(This article belongs to this Special Issue: Cell-Based Regenerative Therapies)

BIOCELL 2022, 46(10), 2231-2234. https://doi.org/10.32604/biocell.2022.020179

Received 09 November 2021; Accepted 07 February 2022; Issue published 13 June 2022

Abstract

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets are topics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative diseases. From pre-transplantation through post-transplantation, there are many changes in the conditions, both inside and outside of the stem cells that have not been carefully considered. This has hindered development in the field of cell therapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellular alterations of stem cells in transplanted areas at risk of neurodegenerative disease.

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Keywords

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