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Magnesium Demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress

XINTING ZHU1,2,#, MENG YE2,3,#, KELAN FANG1, FANG LIU1,2, JING HUI1,2, MEICHEN LIU2, XIAOFEI LI1,2, RONG YAN1,2,*, Yun Liu1,2,4,*

1 Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, 563000, China
2 College of Basic Medicine, Zunyi Medical University, Zunyi, 563000, China
3 Scientific Research Center, The First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, 563000, China
4 School of Forensic Medicine, Zunyi Medical University, Zunyi, 563000, China

* Corresponding Authors: RONG YAN. Email: email; Yun Liu. Email: email
# These authors contributed equally

(This article belongs to the Special Issue: Herbal Active Ingredients: Potential for the Prevention and Treatment of Cancer)

BIOCELL 2022, 46(12), 2595-2600. https://doi.org/10.32604/biocell.2022.025468

Abstract

Cantharidin (CTD) is a bioactive ingredient isolated from Cantharis vesicatoria (blister beetles), which has potential therapeutic value as an anticancer agent. Magnesium Demethylcantharidate (MDC) is a recently developed derivative of Cantharidin (CTD), and previous studies have illustrated its excellent anticancer activity on HCC cells. However, the effect and mechanism of MDC remains unclear and need to be further studied. In particular, whether MDC can cause ER stress in HCC is still unknown. In this study, we demonstrated that endoplasmic reticulum stress (ERS)-related proteins were changed in SMMC-7721 and Bel-7402 cells after being exposed to MDC. Moreover, we found that MDC could significantly inhibit the growth of xenograft tumor in nude mice. In summary, we confirmed that MDC could induce ERS in HCC cells and thus induce apoptosis.

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APA Style
ZHU, X., YE, M., FANG, K., LIU, F., HUI, J. et al. (2022). Magnesium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. BIOCELL, 46(12), 2595-2600. https://doi.org/10.32604/biocell.2022.025468
Vancouver Style
ZHU X, YE M, FANG K, LIU F, HUI J, LIU M, et al. Magnesium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. BIOCELL . 2022;46(12):2595-2600 https://doi.org/10.32604/biocell.2022.025468
IEEE Style
X. ZHU et al., "Magnesium Demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress," BIOCELL , vol. 46, no. 12, pp. 2595-2600. 2022. https://doi.org/10.32604/biocell.2022.025468



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