Open Access

VIEWPOINT

Implant surface features as key role on cell behavior

RAFAEL SCAF DE MOLON^1,2, MARTA MARIA ALVES PEREIRA², ERICA DORIGATTI DE AVILA²

1 Federal University of Rio de Janeiro, Rio de Janeiro, 21941-617, Brazil
2 São Paulo State University, Araraquara, 14801-930, Brazil

* Address correspondence to: Erica Dorigatti de Avila,

BIOCELL 2022, 46(5), 1151-1156. https://doi.org/10.32604/biocell.2022.018026

Received 24 June 2021; Accepted 26 July 2021; Issue published 06 January 2022

Abstract

It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments. Herein, we aimed to discuss, through a science-based viewpoint, the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.

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Keywords

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