Open Access
REVIEW
Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition
MARIANO BIZZARRI*, PAOLA PONTECORVI
Department of Experimental Medicine, Systems Biology Group, Sapienza University of Rome, Rome, 00163, Italy
* Address correspondence to: Mariano Bizzarri,
(This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)
BIOCELL 2022, 46(6), 1357-1362. https://doi.org/10.32604/biocell.2022.018471
Received 27 July 2021; Accepted 16 September 2021; Issue published 07 February 2022
Abstract
The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex
structure that confers stability to cell shape while serving as sensor of internal/extracellular changes.
Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by
fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These
characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk
between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can
be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area
of interest in cancer and developmental biology.
Keywords
Cite This Article
APA Style
BIZZARRI, M., PONTECORVI, P. (2022). Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition. BIOCELL, 46(6), 1357-1362. https://doi.org/10.32604/biocell.2022.018471
Vancouver Style
BIZZARRI M, PONTECORVI P. Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition. BIOCELL . 2022;46(6):1357-1362 https://doi.org/10.32604/biocell.2022.018471
IEEE Style
M. BIZZARRI and P. PONTECORVI, "Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition," BIOCELL , vol. 46, no. 6, pp. 1357-1362. 2022. https://doi.org/10.32604/biocell.2022.018471