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Translational aspects of the modern genetics in head and neck cancers

FRANCESCO PADUANO1,2,*, EMANUELA ALTOMARE2,3, BENEDETTA MARRELLI1, VINCENZO DATTILO4, HAIZAL MOHD HUSSAINI5, PAUL ROY COOPER5, MARCO TATULLO6

1 Marrelli Health-Tecnologica Research Institute, Biomedical Section, Stem Cells and Medical Genetics Units, Crotone, 88900, Italy
2 University “Magna Graecia” of Catanzaro, Catanzaro, 88600, Italy
3 Fondazione “Massimo Marrelli”, Crotone, 88900, Italy
4 Genetics Unit, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, 20125, Italy
5 Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, 9054, New Zealand
6 Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, 70124, Italy

* Corresponding Author: Francesco Paduano, email

BIOCELL 2022, 46(8), 1827-1835. https://doi.org/10.32604/biocell.2022.020462

Abstract

Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases have been systematically investigated for original articles published in the last two years, reporting studies on the main queries addressed in this work. This review also comparatively describes the impact of environmental and pathological co-factors in different types of cancers, clarifying and updating the role of genetic factors in SCCHN onset and development. The main outcomes reported may be helpful to drive clinicians towards their clinical evaluations for the most appropriate therapeutic approach in SCCHN.

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APA Style
PADUANO, F., ALTOMARE, E., MARRELLI, B., DATTILO, V., HUSSAINI, H.M. et al. (2022). Translational aspects of the modern genetics in head and neck cancers. BIOCELL, 46(8), 1827-1835. https://doi.org/10.32604/biocell.2022.020462
Vancouver Style
PADUANO F, ALTOMARE E, MARRELLI B, DATTILO V, HUSSAINI HM, COOPER PR, et al. Translational aspects of the modern genetics in head and neck cancers. BIOCELL . 2022;46(8):1827-1835 https://doi.org/10.32604/biocell.2022.020462
IEEE Style
F. PADUANO et al., "Translational aspects of the modern genetics in head and neck cancers," BIOCELL , vol. 46, no. 8, pp. 1827-1835. 2022. https://doi.org/10.32604/biocell.2022.020462



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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